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10.3892/ijo.2018.4400 http://scihub22266oqcxt.onion/10.3892/ijo.2018.4400 C5958811!5958811!29749477     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Oncol 2018 ; 53 (1): 21-32 Nephropedia Template TP {{tp|p=29749477|t=2018. Long non-coding RNA HOXD-AS1 promotes tumor progression and predicts poor prognosis in colorectal cancer |pdf=|usr=}}{{29749477}} gab.com Text Long non-coding RNA HOXD-AS1 promotes tumor progression and predicts poor prognosis in colorectal cancer JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29749477 #FOAvip Mounting evidence has indicated that long non-coding RNAs (lncRNA) serve important roles in tumor development. Previous studies have demonstrated that the lncRNA HOXD cluster antisense RNA 1 (HOXD-AS1) promotes tumor progression in numerous types of cancer; however, the role of HOXD-AS1 in colorectal cancer (CRC) remains unclear. In the present study, the expression levels of HOXD-AS1 were detected in CRC tissues and cell lines using quantitative polymerase chain reaction. In addition, the biological effects of HOXD-AS1 on CRC were evaluated in vitro by cell counting kit-8, colony formation and Transwell assays, and in vivo by tumorigenesis and metastasis assays. The results demonstrated that HOXD-AS1 was upregulated in CRC tissues and cell lines, and that overexpression of HOXD-AS1 was associated with poor prognosis in patients with CRC. Furthermore, knockdown of HOXD-AS1 inhibited cell proliferation, cell invasion, epithelial-mesenchymal transition and stem cell formation in vitro, as well as tumor growth and metastasis in vivo. Mechanistically, HOXD-AS1 functioned as a competing endogenous RNA for miR-217. In conclusion, the present study demonstrated that HOXD-AS1 may promote CRC progression and metastasis by competing for miR-217. In addition, HOXD-AS1 may be considered an indicator of prognosis in patients with CRC. Twit Text FOAVip Long non-coding RNA HOXD-AS1 promotes tumor progression and predicts poor prognosis in colorectal cancer ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29749477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29749477 #FOAvip English Wikipedia <ref>{{Cite pmid|29749477}}</ref> Long non-coding RNA HOXD-AS1 promotes tumor progression and predicts poor prognosis in colorectal cancer #MMPMID29749477 Li X; Zhao X; Yang B; Li Y; Liu T; Pang L; Fan Z; Ma W; Liu Z; Li Z Int J Oncol 2018[Jul]; 53 (1): 21-32 PMID29749477show ga Mounting evidence has indicated that long non-coding RNAs (lncRNA) serve important roles in tumor development. Previous studies have demonstrated that the lncRNA HOXD cluster antisense RNA 1 (HOXD-AS1) promotes tumor progression in numerous types of cancer; however, the role of HOXD-AS1 in colorectal cancer (CRC) remains unclear. In the present study, the expression levels of HOXD-AS1 were detected in CRC tissues and cell lines using quantitative polymerase chain reaction. In addition, the biological effects of HOXD-AS1 on CRC were evaluated in vitro by cell counting kit-8, colony formation and Transwell assays, and in vivo by tumorigenesis and metastasis assays. The results demonstrated that HOXD-AS1 was upregulated in CRC tissues and cell lines, and that overexpression of HOXD-AS1 was associated with poor prognosis in patients with CRC. Furthermore, knockdown of HOXD-AS1 inhibited cell proliferation, cell invasion, epithelial-mesenchymal transition and stem cell formation in vitro, as well as tumor growth and metastasis in vivo. Mechanistically, HOXD-AS1 functioned as a competing endogenous RNA for miR-217. In conclusion, the present study demonstrated that HOXD-AS1 may promote CRC progression and metastasis by competing for miR-217. In addition, HOXD-AS1 may be considered an indicator of prognosis in patients with CRC. äLong non-coding RNA HOXD-AS1 promotes tumor progression and predicts p(epmc).pdf DeepDyve Pubget Overpricing