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10.3892/ijo.2018.4400 http://scihub22266oqcxt.onion/10.3892/ijo.2018.4400 C5958811!5958811 !29749477     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29749477 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Oncol 2018 ; 53 (1 ): 21-32 Nephropedia Template TP {{tp|p=29749477 |t=2018. Long non-coding RNA HOXD-AS1 promotes tumor progression and predicts poor prognosis in colorectal cancer |pdf=|usr=}}{{29749477 }} gab.com Text Long non-coding RNA HOXD-AS1 promotes tumor progression and predicts poor prognosis in colorectal cancer JO: Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29749477 #FOAvip Mounting evidence has indicated that long non?coding RNAs (lncRNA) serve important roles in tumor development. Previous studies have demonstrated that the lncRNA HOXD cluster antisense RNA 1 (HOXD?AS1) promotes tumor progression in numerous types of cancer; however, the role of HOXD?AS1 in colorectal cancer (CRC) remains unclear. In the present study, the expression levels of HOXD?AS1 were detected in CRC tissues and cell lines using quantitative polymerase chain reaction. In addition, the biological effects of HOXD?AS1 on CRC were evaluated in vitro by cell counting kit?8, colony formation and Transwell assays, and in vivo by tumorigenesis and metastasis assays. The results demonstrated that HOXD?AS1 was upregulated in CRC tissues and cell lines, and that overexpression of HOXD?AS1 was associated with poor prognosis in patients with CRC. Furthermore, knockdown of HOXD?AS1 inhibited cell proliferation, cell invasion, epithelial?mesenchymal transition and stem cell formation in vitro, as well as tumor growth and metastasis in vivo. Mechanistically, HOXD?AS1 functioned as a competing endogenous RNA for miR?217. In conclusion, the present study demonstrated that HOXD?AS1 may promote CRC progression and metastasis by competing for miR?217. In addition, HOXD?AS1 may be considered an indicator of prognosis in patients with CRC. Twit Text FOAVip Long non-coding RNA HOXD-AS1 promotes tumor progression and predicts poor prognosis in colorectal cancer ????Int J Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29749477 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29749477 #FOAvip English Wikipedia <ref>{{Cite pmid|29749477 }}</ref> Long non-coding RNA HOXD-AS1 promotes tumor progression and predicts poor prognosis in colorectal cancer #MMPMID29749477 Li X ; Zhao X ; Yang B ; Li Y ; Liu T ; Pang L ; Fan Z ; Ma W ; Liu Z ; Li Z Int J Oncol 2018[Jul]; 53 (1 ): 21-32 PMID29749477 show ga Mounting evidence has indicated that long non?coding RNAs (lncRNA) serve important roles in tumor development. Previous studies have demonstrated that the lncRNA HOXD cluster antisense RNA 1 (HOXD?AS1) promotes tumor progression in numerous types of cancer; however, the role of HOXD?AS1 in colorectal cancer (CRC) remains unclear. In the present study, the expression levels of HOXD?AS1 were detected in CRC tissues and cell lines using quantitative polymerase chain reaction. In addition, the biological effects of HOXD?AS1 on CRC were evaluated in vitro by cell counting kit?8, colony formation and Transwell assays, and in vivo by tumorigenesis and metastasis assays. The results demonstrated that HOXD?AS1 was upregulated in CRC tissues and cell lines, and that overexpression of HOXD?AS1 was associated with poor prognosis in patients with CRC. Furthermore, knockdown of HOXD?AS1 inhibited cell proliferation, cell invasion, epithelial?mesenchymal transition and stem cell formation in vitro, as well as tumor growth and metastasis in vivo. Mechanistically, HOXD?AS1 functioned as a competing endogenous RNA for miR?217. In conclusion, the present study demonstrated that HOXD?AS1 may promote CRC progression and metastasis by competing for miR?217. In addition, HOXD?AS1 may be considered an indicator of prognosis in patients with CRC. |Aged [MESH] |Carcinogenesis/*genetics [MESH] |Cell Movement/genetics [MESH] |Cell Proliferation/genetics [MESH] |Colorectal Neoplasms/epidemiology/*genetics/pathology [MESH] |Disease-Free Survival [MESH] |Epithelial-Mesenchymal Transition/genetics [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Gene Knockdown Techniques [MESH] |HCT116 Cells [MESH] |Humans [MESH] |Kaplan-Meier Estimate [MESH] |Male [MESH] |MicroRNAs/*genetics [MESH] |Middle Aged [MESH] |Neoplasm Invasiveness/genetics/pathology [MESH] |Prognosis [MESH]Long non-coding RNA HOXD-AS1 promotes tumor progression and predicts p(epmc).pdf DeepDyve Pubget Overpricing