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10.3892/ol.2018.8441 http://scihub22266oqcxt.onion/10.3892/ol.2018.8441 C5958710!5958710 !29805610     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29805610 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncol+Lett 2018 ; 15 (6 ): 8723-8728 Nephropedia Template TP {{tp|p=29805610 |t=2018. Transforming growth factor-? decreases side population cells in hepatocellular carcinoma in vitro |pdf=|usr=}}{{29805610 }} gab.com Text Transforming growth factor- decreases side population cells in hepatocellular carcinoma in vitro JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29805610 #FOAvip Hepatocellular carcinoma (HCC) can result from hepatitis B or C infection, fibrosis or cirrhosis. Transforming growth factor-? (TGF-?) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role is controversial in hepatocarcinogenesis. In the present study, the effect of TGF-? on the HCC Huh-7 and Huh-Bat cell lines was evaluated. To study the effect of TGF-?, Huh-7 and Huh-Bat cells were treated with TGF-? and a TGF-? receptor inhibitor (SB431542). Cell survival, cell cycle, numbers of side population (SP) cells and expression of the cancer stem cell marker cluster of differentiation (CD)133, epithelial-mesenchymal transition markers (E-cadherin, ?-smooth muscle actin and vimentin) and TGF-?-regulated proteins [phospho-c-Jun N-terminal kinase (p-JNK), p-c-Jun and p-smad2] were investigated. TGF-? treatment resulted in decreased cell survival with a targeted effect on SP cells. Expression of CD133 and vimentin was upregulated by treatment with the TGF-? receptor antagonist SB431542, but not with TGF-?. By contrast, TGF-? induced accumulation of cells at G0/G1, and upregulated expression of p-JNK, p-c-Jun and p-smad2. However, these effects were blocked when cells were treated with TGF-? plus SB431542, indicating the specificity of the TGF-? effect. The present results indicated that TGF-? has anticancer effects mediated by survival inhibition of cancer stem cells, which may be developed as a novel therapy for HCC. Twit Text FOAVip Transforming growth factor- decreases side population cells in hepatocellular carcinoma in vitro ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=29805610 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29805610 #FOAvip English Wikipedia <ref>{{Cite pmid|29805610 }}</ref> Transforming growth factor-? decreases side population cells in hepatocellular carcinoma in vitro #MMPMID29805610 Kim JB ; Lee S ; Kim HR ; Park SY ; Lee M ; Yoon JH ; Kim YJ Oncol Lett 2018[Jun]; 15 (6 ): 8723-8728 PMID29805610 show ga Hepatocellular carcinoma (HCC) can result from hepatitis B or C infection, fibrosis or cirrhosis. Transforming growth factor-? (TGF-?) is one of the main growth factors associated with fibrosis or cirrhosis progression in the liver, but its role is controversial in hepatocarcinogenesis. In the present study, the effect of TGF-? on the HCC Huh-7 and Huh-Bat cell lines was evaluated. To study the effect of TGF-?, Huh-7 and Huh-Bat cells were treated with TGF-? and a TGF-? receptor inhibitor (SB431542). Cell survival, cell cycle, numbers of side population (SP) cells and expression of the cancer stem cell marker cluster of differentiation (CD)133, epithelial-mesenchymal transition markers (E-cadherin, ?-smooth muscle actin and vimentin) and TGF-?-regulated proteins [phospho-c-Jun N-terminal kinase (p-JNK), p-c-Jun and p-smad2] were investigated. TGF-? treatment resulted in decreased cell survival with a targeted effect on SP cells. Expression of CD133 and vimentin was upregulated by treatment with the TGF-? receptor antagonist SB431542, but not with TGF-?. By contrast, TGF-? induced accumulation of cells at G0/G1, and upregulated expression of p-JNK, p-c-Jun and p-smad2. However, these effects were blocked when cells were treated with TGF-? plus SB431542, indicating the specificity of the TGF-? effect. The present results indicated that TGF-? has anticancer effects mediated by survival inhibition of cancer stem cells, which may be developed as a novel therapy for HCC. äTransforming growth factor-? decreases side population cells in hepato(epmc).pdf DeepDyve Pubget Overpricing