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10.1038/s41598-018-26102-3 http://scihub22266oqcxt.onion/10.1038/s41598-018-26102-3 C5958102!5958102 !29773845     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29773845 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2018 ; 8 (1 ): 7801 Nephropedia Template TP {{tp|p=29773845 |t=2018. AICAR inhibits NF?B DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages |pdf=|usr=}}{{29773845 }} gab.com Text AICAR inhibits NF B DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29773845 #FOAvip 5-aminoimidazole-4-carboxamide-1-?-D-ribofuranoside (AICAR) is an established pharmacological activator of AMP-activated protein kinase (AMPK). Both, AICAR and AMPK were reported to attenuate inflammation. However, AICAR is known for many AMPK-independent effects, although the mechanisms remain incompletely understood. Here we report a potent suppression of lipopolysaccharide (LPS)-induced inflammatory gene expression by AICAR in primary human macrophages, which occurred independently of its conversion to AMPK-activating 5-aminoimidazole-4-carboxamide-1-?-D-ribofuranosyl monophosphate. Although AICAR did not interfere with activation of cytosolic signalling cascades and nuclear translocation of nuclear factor - ?B (NF?B) by LPS, it prevented the recruitment of NF?B and RNA polymerase II to target gene promoters. AICAR also inhibited signal transducer and activator of transcription 3 (STAT3)-dependent induction of interleukin (IL) IL-6 and IL-10 targets, while leaving STAT6 and HIF1?-dependent gene expression in IL-4 and dimethyloxalylgylcine-treated macrophages intact. This points to a transcription factor-specific mode of action. Attenuated gene expression correlated with impaired NF?B and STAT3, but not HIF-binding in electrophoretic mobility shift assays in vitro. Conclusively, AICAR interferes with DNA binding of NF?B and STAT3 to modulate inflammatory responses. Twit Text FOAVip AICAR inhibits NF B DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29773845 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29773845 #FOAvip English Wikipedia <ref>{{Cite pmid|29773845 }}</ref> AICAR inhibits NF?B DNA binding independently of AMPK to attenuate LPS-triggered inflammatory responses in human macrophages #MMPMID29773845 Kirchner J ; Brüne B ; Namgaladze D Sci Rep 2018[May]; 8 (1 ): 7801 PMID29773845 show ga 5-aminoimidazole-4-carboxamide-1-?-D-ribofuranoside (AICAR) is an established pharmacological activator of AMP-activated protein kinase (AMPK). Both, AICAR and AMPK were reported to attenuate inflammation. However, AICAR is known for many AMPK-independent effects, although the mechanisms remain incompletely understood. Here we report a potent suppression of lipopolysaccharide (LPS)-induced inflammatory gene expression by AICAR in primary human macrophages, which occurred independently of its conversion to AMPK-activating 5-aminoimidazole-4-carboxamide-1-?-D-ribofuranosyl monophosphate. Although AICAR did not interfere with activation of cytosolic signalling cascades and nuclear translocation of nuclear factor - ?B (NF?B) by LPS, it prevented the recruitment of NF?B and RNA polymerase II to target gene promoters. AICAR also inhibited signal transducer and activator of transcription 3 (STAT3)-dependent induction of interleukin (IL) IL-6 and IL-10 targets, while leaving STAT6 and HIF1?-dependent gene expression in IL-4 and dimethyloxalylgylcine-treated macrophages intact. This points to a transcription factor-specific mode of action. Attenuated gene expression correlated with impaired NF?B and STAT3, but not HIF-binding in electrophoretic mobility shift assays in vitro. Conclusively, AICAR interferes with DNA binding of NF?B and STAT3 to modulate inflammatory responses. |AMP-Activated Protein Kinases/*metabolism [MESH] |Aminoimidazole Carboxamide/*analogs & derivatives/pharmacology [MESH] |Gene Expression Regulation/drug effects [MESH] |Humans [MESH] |Lipopolysaccharides [MESH] |Macrophages/*drug effects/immunology/metabolism [MESH] |NF-kappa B/drug effects/metabolism [MESH]AICAR inhibits NF?B DNA binding independently of AMPK to attenuate LPS(epmc).pdf DeepDyve Pubget Overpricing