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10.1038/s41467-018-04379-2 http://scihub22266oqcxt.onion/10.1038/s41467-018-04379-2 C5958057!5958057!29773792     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2018 ; 9 (ä): ä Nephropedia Template TP {{tp|p=29773792|t=2018. MxB is an interferon-induced restriction factor of human herpesviruses |pdf=|usr=}}{{29773792}} gab.com Text MxB is an interferon-induced restriction factor of human herpesviruses JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29773792 #FOAvip The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi?s sarcoma-associated herpesvirus (KSHV). MxB restriction of HSV-1 and HSV-2 requires GTPase function, in contrast to restriction of lentiviruses. MxB inhibits the delivery of incoming HSV-1 DNA to the nucleus and the appearance of empty capsids, but not the capsid delivery to the cytoplasm or tegument dissociation from the capsid. Our study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid. Twit Text FOAVip MxB is an interferon-induced restriction factor of human herpesviruses ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29773792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29773792 #FOAvip English Wikipedia <ref>{{Cite pmid|29773792}}</ref> MxB is an interferon-induced restriction factor of human herpesviruses #MMPMID29773792 Crameri M; Bauer M; Caduff N; Walker R; Steiner F; Franzoso FD; Gujer C; Boucke K; Kucera T; Zbinden A; Münz C; Fraefel C; Greber UF; Pavlovic J Nat Commun 2018[]; 9 (ä): ä PMID29773792show ga The type I interferon (IFN) system plays an important role in controlling herpesvirus infections, but it is unclear which IFN-mediated effectors interfere with herpesvirus replication. Here we report that human myxovirus resistance protein B (MxB, also designated Mx2) is a potent human herpesvirus restriction factor in the context of IFN. We demonstrate that ectopic MxB expression restricts a range of herpesviruses from the Alphaherpesvirinae and Gammaherpesvirinae, including herpes simplex virus 1 and 2 (HSV-1 and HSV-2), and Kaposi?s sarcoma-associated herpesvirus (KSHV). MxB restriction of HSV-1 and HSV-2 requires GTPase function, in contrast to restriction of lentiviruses. MxB inhibits the delivery of incoming HSV-1 DNA to the nucleus and the appearance of empty capsids, but not the capsid delivery to the cytoplasm or tegument dissociation from the capsid. Our study identifies MxB as a potent pan-herpesvirus restriction factor which blocks the uncoating of viral DNA from the incoming viral capsid. äMxB is an interferon-induced restriction factor of human herpesviruses(epmc).pdf DeepDyve Pubget Overpricing