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2018 ; 13
(5
): e0197295
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Nonparametric estimation of median survival times with applications to multi-site
or multi-center studies
#MMPMID29772007
Rahbar MH
; Choi S
; Hong C
; Zhu L
; Jeon S
; Gardiner JC
PLoS One
2018[]; 13
(5
): e0197295
PMID29772007
show ga
We propose a nonparametric shrinkage estimator for the median survival times from
several independent samples of right-censored data, which combines the samples
and hypothesis information to improve the efficiency. We compare efficiency of
the proposed shrinkage estimation procedure to unrestricted estimator and
combined estimator through extensive simulation studies. Our results indicate
that performance of these estimators depends on the strength of homogeneity of
the medians. When homogeneity holds, the combined estimator is the most efficient
estimator. However, it becomes inconsistent when homogeneity fails. On the other
hand, the proposed shrinkage estimator remains efficient. Its efficiency
decreases as the equality of the survival medians is deviated, but is expected to
be as good as or equal to the unrestricted estimator. Our simulation studies also
indicate that the proposed shrinkage estimator is robust to moderate levels of
censoring. We demonstrate application of these methods to estimating median time
for trauma patients to receive red blood cells in the Prospective Observational
Multi-center Major Trauma Transfusion (PROMMTT) study.