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10.1126/science.aao2602 http://scihub22266oqcxt.onion/10.1126/science.aao2602 C5957278!5957278!28935768     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2017 ; 358 (6360): ä Nephropedia Template TP {{tp|p=28935768|t=2017. The Microanatomic Segregation of Selection by Apoptosis in the Germinal Center |pdf=|usr=}}{{28935768}} gab.com Text The Microanatomic Segregation of Selection by Apoptosis in the Germinal Center JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=28935768 #FOAvip B cells undergo rapid cell division and affinity maturation in anatomically distinct sites in lymphoid organs called germinal centers (GCs). Homeostasis is maintained in part by B-cell apoptosis. However, the precise contribution of apoptosis to GC biology and selection is not well defined. We developed apoptosis-indicator mice and used them to visualize, purify, and characterize dying GC B cells. Apoptosis is prevalent in the GC with up to half of all GC B cells dying every 6h. Moreover, programmed cell death is differentially regulated in the light zone (LZ) and the dark zone (DZ): LZ B cells die by default if they are not positively selected, whereas DZ cells die when their antigen receptors are damaged by activation-induced cytidine deaminase (AID). Twit Text FOAVip The Microanatomic Segregation of Selection by Apoptosis in the Germinal Center ????Science http://www.kidney.de/pget.php?&tw=1&pmid=28935768 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28935768 #FOAvip English Wikipedia <ref>{{Cite pmid|28935768}}</ref> The Microanatomic Segregation of Selection by Apoptosis in the Germinal Center #MMPMID28935768 Mayer CT; Gazumyan A; Kara EE; Gitlin AD; Golijanin J; Viant C; Pai J; Oliveira TY; Wang Q; Escolano A; Medina-Ramirez M; Sanders RW; Nussenzweig MC Science 2017[Oct]; 358 (6360): ä PMID28935768show ga B cells undergo rapid cell division and affinity maturation in anatomically distinct sites in lymphoid organs called germinal centers (GCs). Homeostasis is maintained in part by B-cell apoptosis. However, the precise contribution of apoptosis to GC biology and selection is not well defined. We developed apoptosis-indicator mice and used them to visualize, purify, and characterize dying GC B cells. Apoptosis is prevalent in the GC with up to half of all GC B cells dying every 6h. Moreover, programmed cell death is differentially regulated in the light zone (LZ) and the dark zone (DZ): LZ B cells die by default if they are not positively selected, whereas DZ cells die when their antigen receptors are damaged by activation-induced cytidine deaminase (AID). äThe Microanatomic Segregation of Selection by Apoptosis in the Germina(epmc).pdf DeepDyve Pubget Overpricing