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10.3233/JAD-170948 http://scihub22266oqcxt.onion/10.3233/JAD-170948 C5956916!5956916 !29480193     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29480193 &cmd=llinks): Failed to open stream: HTTP request failed! 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Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer s Disease |pdf=|usr=}}{{29480193 }} gab.com Text Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer s Disease JO: J Alzheimers Dis http://www.kidney.de/pget.php?&tw=1&pmid=29480193 #FOAvip Studies suggest that a single injection of pramlintide, an amylin analog, induces changes in Alzheimer's disease (AD) biomarkers in the blood of AD mouse models and AD patients. The aim of this study was to examine whether a pramlintide challenge combined with a phosphatidylcholine (PC) profile diagnoses of AD and mild cognitive impairment (MCI) better than PC alone. Non-diabetic subjects with cognitive status were administered a single subcutaneous injection of 60 mcg of pramlintide under fasting condition. A total of 71 PCs, amyloid-? peptide (A?), and total tau (t-tau) in plasma at different time points were measured and treated as individual variables. A single injection of pramlintide altered the levels of 7 PCs in the blood, while a pramlintide injection plus food modulated the levels of 10 PCs in the blood (p?<?0.05). The levels of 2 PCs in MCI and 12 PCs in AD in the pramlintide challenge were significantly lower than the ones in controls. We found that while some PCs were associated with only A? levels, other PCs were associated with both A? and t-tau levels. A receiver operating characteristic analysis of the PCs was combined with the A? and t-tau data to produce an area under the curve predictive value of 0.9799 between MCI subjects and controls, 0.9794 between AD subjects and controls, and 0.9490 between AD and MCI subjects. A combination of AD biomarkers and a group of PCs post a pramlintide challenge may provide a valuable diagnostic and prognostic test for AD and MCI. Twit Text FOAVip Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer s Disease ????J Alzheimers Dis http://www.kidney.de/pget.php?&tw=1&pmid=29480193 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29480193 #FOAvip English Wikipedia <ref>{{Cite pmid|29480193 }}</ref> Pramlintide: The Effects of a Single Drug Injection on Blood Phosphatidylcholine Profile for Alzheimer s Disease #MMPMID29480193 Tao Q ; Zhu H ; Chen X ; Stern RA ; Kowall N ; Au R ; Blusztajn JK ; Qiu WQ J Alzheimers Dis 2018[]; 62 (2 ): 597-609 PMID29480193 show ga Studies suggest that a single injection of pramlintide, an amylin analog, induces changes in Alzheimer's disease (AD) biomarkers in the blood of AD mouse models and AD patients. The aim of this study was to examine whether a pramlintide challenge combined with a phosphatidylcholine (PC) profile diagnoses of AD and mild cognitive impairment (MCI) better than PC alone. Non-diabetic subjects with cognitive status were administered a single subcutaneous injection of 60 mcg of pramlintide under fasting condition. A total of 71 PCs, amyloid-? peptide (A?), and total tau (t-tau) in plasma at different time points were measured and treated as individual variables. A single injection of pramlintide altered the levels of 7 PCs in the blood, while a pramlintide injection plus food modulated the levels of 10 PCs in the blood (p? |Aged [MESH] |Aged, 80 and over [MESH] |Alzheimer Disease/blood/*diagnosis [MESH] |Amyloid beta-Peptides/blood [MESH] |Biomarkers/blood [MESH] |Cognitive Dysfunction/blood/*diagnosis [MESH] |Female [MESH] |Humans [MESH] |Islet Amyloid Polypeptide/*administration & dosage [MESH] |Logistic Models [MESH] |Male [MESH] |Middle Aged [MESH] |Phosphatidylcholines/*blood [MESH] |ROC Curve [MESH]Pramlintide: The Effects of a Single Drug Injection on Blood Phosphati(epmc).pdf DeepDyve Pubget Overpricing