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10.1016/j.ajoc.2018.03.006

http://scihub22266oqcxt.onion/10.1016/j.ajoc.2018.03.006
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C5956714!5956714!29780945
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suck abstract from ncbi


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pmid29780945      Am+J+Ophthalmol+Case+Rep 2018 ; 10 (ä): 253-6
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  • Treatment challenges in an atypical presentation of tubulointerstitial nephritis and uveitis (TINU) #MMPMID29780945
  • Caplash S; Gangaputra S; Kodati S; Tuchman S; Srinivasalu H; Sen HN
  • Am J Ophthalmol Case Rep 2018[Jun]; 10 (ä): 253-6 PMID29780945show ga
  • Purpose: To describe an atypical presentation of Tubulointerstitial Nephritis and Uveitis (TINU), with challenges in treatment course. Observations: A 12-year-old Hispanic female presented to the National Eye Institute's Uveitis clinic with bilateral blurred vision, red eyes and photophobia, not responsive to topical steroids. On exam, she had bilateral severe panuveitis with areas of subretinal fluid. During her evaluation, she was noted to have elevated serum creatinine. A kidney biopsy confirmed the presence of severe tubulointerstitial nephritis and interstitial fibrosis. She was treated with oral steroids with excellent resolution of symptoms and subretinal fluid. She continued to have anterior segment flares with attempts to taper oral prednisone which lead to treatment with multiple immunomodulatory agents. Associated hypertension and kidney damage complicated the choice of a secondary immunosuppressive agent. Conclusions and Importance: Although rare, TINU can present as panuveitis with choroidal involvement which may or may not be preceded by tubulointerstitial nephritis. A renal biopsy is required for definitive diagnosis, but abnormal urinalysis or renal function should raise suspicion for TINU.
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