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10.1021/acs.jpclett.6b01066 http://scihub22266oqcxt.onion/10.1021/acs.jpclett.6b01066 C5956519!5956519!27387853     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Phys+Chem+Lett 2016 ; 7 (14): 2758-64 Nephropedia Template TP {{tp|p=27387853|t=2016. Structural and Mechanical Properties of Amyloid Beta Fibrils: A Combined Experimental and Theoretical Approach |pdf=|usr=}}{{27387853}} gab.com Text Structural and Mechanical Properties of Amyloid Beta Fibrils: A Combined Experimental and Theoretical Approach JO: J Phys Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=27387853 #FOAvip In this combined experimental (deep ultraviolet resonance Raman (DUVRR) spectroscopy and atomic force microscopy (AFM)) and theoretical (molecular dynamics (MD) simulations and stress?strain (SS)) study, the structural and mechanical properties of amyloid beta (A?40) fibrils have been investigated. The DUVRR spectroscopy and AFM experiments confirmed the formation of linear, unbranched and ?-sheet rich fibrils. The fibrils (A?40)n, formed using n monomers, were equilibrated using all-atom MD simulations. The structural properties such as ?-sheet character, twist, interstrand distance, and periodicity of these fibrils were found to be in agreement with experimental measurements. Furthermore, Young?s modulus (Y) = 4.2 GPa computed using SS calculations was supported by measured values of 1.79 ± 0.41 and 3.2 ± 0.8 GPa provided by two separate AFM experiments. These results revealed size dependence of structural and material properties of amyloid fibrils and show the utility of such combined experimental and theoretical studies in the design of precisely engineered biomaterials. Twit Text FOAVip Structural and Mechanical Properties of Amyloid Beta Fibrils: A Combined Experimental and Theoretical Approach ????J Phys Chem Lett http://www.kidney.de/pget.php?&tw=1&pmid=27387853 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27387853 #FOAvip English Wikipedia <ref>{{Cite pmid|27387853}}</ref> Structural and Mechanical Properties of Amyloid Beta Fibrils: A Combined Experimental and Theoretical Approach #MMPMID27387853 Paul TJ; Hoffmann Z; Wang C; Shanmugasundaram M; DeJoannis J; Shekhtman A; Lednev IK; Yadavalli VK; Prabhakar R J Phys Chem Lett 2016[Jul]; 7 (14): 2758-64 PMID27387853show ga In this combined experimental (deep ultraviolet resonance Raman (DUVRR) spectroscopy and atomic force microscopy (AFM)) and theoretical (molecular dynamics (MD) simulations and stress?strain (SS)) study, the structural and mechanical properties of amyloid beta (A?40) fibrils have been investigated. The DUVRR spectroscopy and AFM experiments confirmed the formation of linear, unbranched and ?-sheet rich fibrils. The fibrils (A?40)n, formed using n monomers, were equilibrated using all-atom MD simulations. The structural properties such as ?-sheet character, twist, interstrand distance, and periodicity of these fibrils were found to be in agreement with experimental measurements. Furthermore, Young?s modulus (Y) = 4.2 GPa computed using SS calculations was supported by measured values of 1.79 ± 0.41 and 3.2 ± 0.8 GPa provided by two separate AFM experiments. These results revealed size dependence of structural and material properties of amyloid fibrils and show the utility of such combined experimental and theoretical studies in the design of precisely engineered biomaterials. äStructural and Mechanical Properties of Amyloid Beta Fibrils: A Combin(epmc).pdf DeepDyve Pubget Overpricing