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New insights of Helicobacter pylori host-pathogen interactions: The triangle of
virulence factors, epigenetic modifications and non-coding RNAs
#MMPMID29774218
Vaziri F
; Tarashi S
; Fateh A
; Siadat SD
World J Clin Cases
2018[May]; 6
(5
): 64-73
PMID29774218
show ga
Helicobacter pylori (H. pylori) is a model organism for understanding
host-pathogen interactions and infection-mediated carcinogenesis. Gastric cancer
and H. pylori colonization indicates the strong correlation. The progression and
exacerbation of H. pylori infection are influenced by some factors of pathogen
and host. Several virulence factors involved in the proper adherence and
attenuation of immune defense to contribute the risk of emerging gastric cancer,
therefore analysis of them is very important. H. pylori also modulates
inflammatory and autophagy process to intensify its pathogenicity. From the host
regard, different genetic factors particularly affect the development of gastric
cancer. Indeed, epigenetic modifications, MicroRNA and long non-coding RNA
received more attention. Generally, various factors related to pathogen and host
that modulate gastric cancer development in response to H. pylori need more
attention due to develop an efficacious therapeutic intervention. Therefore, this
paper will present a brief overview of host-pathogen interaction especially
emphases on bacterial virulence factors, interruption of host cellular signaling,
the role of epigenetic modifications and non-coding RNAs.
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