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10.18632/oncotarget.24562 http://scihub22266oqcxt.onion/10.18632/oncotarget.24562 C5955403!5955403 !29796175     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29796175 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2018 ; 9 (33 ): 23102-23113 Nephropedia Template TP {{tp|p=29796175 |t=2018. A targeted transforming growth factor-beta (TGF-?) blocker, TTB, inhibits tumor growth and metastasis |pdf=|usr=}}{{29796175 }} gab.com Text A targeted transforming growth factor-beta (TGF- ) blocker, TTB, inhibits tumor growth and metastasis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29796175 #FOAvip Transforming growth factor beta (TGF-?) promotes cancer growth in late stage cancers. To inhibit the TGF-? pathway, we investigated a tumor-targeting TGF-? receptor blocker, TTB, and its role in tumor progress. The targeted TTB comprised of the extracellular domain of the TGF-? receptor II, the endoglin domain of TGF-? receptor III, and the human immuno-globin IgG1 constant fragment (Fc). To enhance tumor microenvironment targeting, a RGD peptide was fused at the N-terminal of TTB. The targeted TTB exhibited potent TGF-? neutralization activities, and inhibited cancer cell migration and invasion as well as colony formation. In xenograft models, the TTB had potent tumor inhibition activities. The TTB also attenuated the TGF-?1-induced Smad2 phosphorylation and epithelial to mesenchymal transformation (EMT), and suppressed breast cancer metastasis. Thus, the TTB is an effective TGF-? blocker with a potential for blocking excessive TGF-? induced pathogenesis in vivo. Twit Text FOAVip A targeted transforming growth factor-beta (TGF- ) blocker, TTB, inhibits tumor growth and metastasis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29796175 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29796175 #FOAvip English Wikipedia <ref>{{Cite pmid|29796175 }}</ref> A targeted transforming growth factor-beta (TGF-?) blocker, TTB, inhibits tumor growth and metastasis #MMPMID29796175 Zhou C ; Li J ; Lin L ; Shu R ; Dong B ; Cao D ; Li Q ; Wang Z Oncotarget 2018[May]; 9 (33 ): 23102-23113 PMID29796175 show ga Transforming growth factor beta (TGF-?) promotes cancer growth in late stage cancers. To inhibit the TGF-? pathway, we investigated a tumor-targeting TGF-? receptor blocker, TTB, and its role in tumor progress. The targeted TTB comprised of the extracellular domain of the TGF-? receptor II, the endoglin domain of TGF-? receptor III, and the human immuno-globin IgG1 constant fragment (Fc). To enhance tumor microenvironment targeting, a RGD peptide was fused at the N-terminal of TTB. The targeted TTB exhibited potent TGF-? neutralization activities, and inhibited cancer cell migration and invasion as well as colony formation. In xenograft models, the TTB had potent tumor inhibition activities. The TTB also attenuated the TGF-?1-induced Smad2 phosphorylation and epithelial to mesenchymal transformation (EMT), and suppressed breast cancer metastasis. Thus, the TTB is an effective TGF-? blocker with a potential for blocking excessive TGF-? induced pathogenesis in vivo. äA targeted transforming growth factor-beta (TGF-?) blocker, TTB, inhib(epmc).pdf DeepDyve Pubget Overpricing