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10.18632/oncotarget.25153 http://scihub22266oqcxt.onion/10.18632/oncotarget.25153 C5955165!5955165!29774119     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2018 ; 9 (31): 22023-37 Nephropedia Template TP {{tp|p=29774119|t=2018. Periostin, a signal transduction intermediate in TGF-?-induced EMT in U-87MG human glioblastoma cells, and its inhibition by anthocyanidins |pdf=|usr=}}{{29774119}} gab.com Text Periostin, a signal transduction intermediate in TGF- -induced EMT in U-87MG human glioblastoma cells, and its inhibition by anthocyanidins JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29774119 #FOAvip Periostin is a secreted protein that is highly expressed in glioblastoma cells as compared to normal brain tissue, and is therefore considered as a potential biomarker in therapeutic modalities. Its contribution in the cancer cells invasive phenotype is, however, poorly understood. This work investigates the role of periostin in U-87 MG glioblastoma cell invasion, cell migration and in Transforming Growth Factor ? (TGF-?)-induced epithelial-mesenchymal transition (EMT). Periostin gene silencing, using small interfering RNA, decreased TGF-?-induced mesenchymal marker expression of fibronectin and vimentin, partly through reduced Smad2, Akt and Fak phosphorylation as well as U-87 MG cell invasion and migration. The effects of anthocyanidins, the most abundant diet-derived flavonoids, were examined on periostin-mediated downstream signaling pathways. Anthocyanidins were found to decrease periostin expression whether added under pre-, co- or post-treatment conditions along with TGF-?, and altered the Akt and Fak signaling pathways. These effects were similar to Galunisertib (LY2157299), a small molecule inhibitor of the TGF-? receptor I kinase. Taken together, our data demonstrate that periostin acts as a central element in TGF-?-induced EMT, which can be prevented by diet-derived anthocyanidins. Twit Text FOAVip Periostin, a signal transduction intermediate in TGF- -induced EMT in U-87MG human glioblastoma cells, and its inhibition by anthocyanidins ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29774119 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29774119 #FOAvip English Wikipedia <ref>{{Cite pmid|29774119}}</ref> Periostin, a signal transduction intermediate in TGF-?-induced EMT in U-87MG human glioblastoma cells, and its inhibition by anthocyanidins #MMPMID29774119 Ouanouki A; Lamy S; Annabi B Oncotarget 2018[Apr]; 9 (31): 22023-37 PMID29774119show ga Periostin is a secreted protein that is highly expressed in glioblastoma cells as compared to normal brain tissue, and is therefore considered as a potential biomarker in therapeutic modalities. Its contribution in the cancer cells invasive phenotype is, however, poorly understood. This work investigates the role of periostin in U-87 MG glioblastoma cell invasion, cell migration and in Transforming Growth Factor ? (TGF-?)-induced epithelial-mesenchymal transition (EMT). Periostin gene silencing, using small interfering RNA, decreased TGF-?-induced mesenchymal marker expression of fibronectin and vimentin, partly through reduced Smad2, Akt and Fak phosphorylation as well as U-87 MG cell invasion and migration. The effects of anthocyanidins, the most abundant diet-derived flavonoids, were examined on periostin-mediated downstream signaling pathways. Anthocyanidins were found to decrease periostin expression whether added under pre-, co- or post-treatment conditions along with TGF-?, and altered the Akt and Fak signaling pathways. These effects were similar to Galunisertib (LY2157299), a small molecule inhibitor of the TGF-? receptor I kinase. Taken together, our data demonstrate that periostin acts as a central element in TGF-?-induced EMT, which can be prevented by diet-derived anthocyanidins. äPeriostin, a signal transduction intermediate in TGF-?-induced EMT in (epmc).pdf DeepDyve Pubget Overpricing