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10.1158/2326-6066.CIR-13-0226 http://scihub22266oqcxt.onion/10.1158/2326-6066.CIR-13-0226 C5955000!5955000!25600437     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Immunol+Res 2015 ; 3 (6): 661-7 Nephropedia Template TP {{tp|p=25600437|t=2015. Fine-Tuning Tumor Immunity With Integrin Trans-regulation |pdf=|usr=}}{{25600437}} gab.com Text Fine-Tuning Tumor Immunity With Integrin Trans-regulation JO: Cancer Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=25600437 #FOAvip Inefficient T-cell homing to tissues limits adoptive T-cell immunotherapy of solid tumors. ?L?2 and ?4?1 integrins mediate trafficking of T cells into tissues via engagement of ICAM-1 and VCAM-1, respectively. Inhibiting Protein Kinase A(PKA)-mediated phosphorylation of ?4 integrin in cells results in an increase in ?L?2-mediated migration on mixed ICAM-1-VCAM-1 substrates in vitro, a phenomenon termed ?integrin trans-regulation.? Here we created an ?4(S988A)-bearing mouse, which precludes PKA-mediated ?4 phosphorylation, to examine the effect of integrin trans-regulation in vivo. The ?4(S988A) mouse exhibited a dramatic and selective increase in migration of lymphocytes, but not myeloid cells, to sites of inflammation. Importantly, we found that the ?4(S988A) mice exhibited a marked increase in T cell entry into and reduced growth of B16 melanomas, consistent with anti-tumor roles of infiltrating T cells and pro-growth functions of tumor-associated macrophages. Thus, increased ?4 trans-regulation of ?L?2 integrin function biases leukocyte emigration towards lymphocytes relative to myeloid cells and enhances tumor immunity. Twit Text FOAVip Fine-Tuning Tumor Immunity With Integrin Trans-regulation ????Cancer Immunol Res http://www.kidney.de/pget.php?&tw=1&pmid=25600437 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25600437 #FOAvip English Wikipedia <ref>{{Cite pmid|25600437}}</ref> Fine-Tuning Tumor Immunity With Integrin Trans-regulation #MMPMID25600437 Cantor JM; Rose DM; Slepak M; Ginsberg MH Cancer Immunol Res 2015[Jun]; 3 (6): 661-7 PMID25600437show ga Inefficient T-cell homing to tissues limits adoptive T-cell immunotherapy of solid tumors. ?L?2 and ?4?1 integrins mediate trafficking of T cells into tissues via engagement of ICAM-1 and VCAM-1, respectively. Inhibiting Protein Kinase A(PKA)-mediated phosphorylation of ?4 integrin in cells results in an increase in ?L?2-mediated migration on mixed ICAM-1-VCAM-1 substrates in vitro, a phenomenon termed ?integrin trans-regulation.? Here we created an ?4(S988A)-bearing mouse, which precludes PKA-mediated ?4 phosphorylation, to examine the effect of integrin trans-regulation in vivo. The ?4(S988A) mouse exhibited a dramatic and selective increase in migration of lymphocytes, but not myeloid cells, to sites of inflammation. Importantly, we found that the ?4(S988A) mice exhibited a marked increase in T cell entry into and reduced growth of B16 melanomas, consistent with anti-tumor roles of infiltrating T cells and pro-growth functions of tumor-associated macrophages. Thus, increased ?4 trans-regulation of ?L?2 integrin function biases leukocyte emigration towards lymphocytes relative to myeloid cells and enhances tumor immunity. äFine-Tuning Tumor Immunity With Integrin Trans-regulation (epmc).pdf DeepDyve Pubget Overpricing