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From blood coagulation to innate and adaptive immunity: the role of platelets in
the physiology and pathology of autoimmune disorders
#MMPMID29492586
?ukasik ZM
; Makowski M
; Makowska JS
Rheumatol Int
2018[Jun]; 38
(6
): 959-974
PMID29492586
show ga
Thrombosis and cardiovascular complications are common manifestations of a
variety of pathological conditions, including infections and chronic inflammatory
diseases. Hence, there is great interest in determining the hitherto unforeseen
immune role of the main blood coagulation executor-the platelet. Platelets store
and release a plethora of immunoactive molecules, generate microparticles, and
interact with cells classically belonging to the immune system. The observed
effects of platelet involvement in immune processes, especially in autoimmune
diseases, are conflicting-from inciting inflammation to mediating its resolution.
An in-depth understanding of the role of platelets in inflammation and immunity
could open new therapeutic pathways for patients with autoimmune disorders. This
review aims to summarize the current knowledge on the role of platelets in the
patomechanisms of autoimmune disorders and suggests directions for future
research.
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