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10.1515/jccm-2015-0007 http://scihub22266oqcxt.onion/10.1515/jccm-2015-0007 C5953291!5953291!29967815     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Crit+Care+Med+(Targu+Mures) 2015 ; 1 (2): 43-54 Nephropedia Template TP {{tp|p=29967815|t=2015. Statins as Pleiotropic Modifiers of Vascular Oxidative Stress and Inflammation |pdf=|usr=}}{{29967815}} gab.com Text Statins as Pleiotropic Modifiers of Vascular Oxidative Stress and Inflammation JO: J Crit Care Med (Targu Mures) http://www.kidney.de/pget.php?&tw=1&pmid=29967815 #FOAvip Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the industrialized world and in the future is expected to be the number one killer worldwide. The main cause underlying CVD is atherosclerosis. A key event in atherosclerosis initiation and progression is oxidative stress through the production of reactive oxygen species as well as endothelial dysfunction. Several pro- inflammatory and anti-inflammatory cytokines and proteins are involved in this process, complemented by activation of adhesion molecules that promote leukocyte rolling, tethering and infiltration into the sub-endothelial space. Statins represent the agent of choice since numerous clinical trials have verified that their pharmacological action extends beyond lipid lowering. Statins demonstrate direct anti-oxidant effects by scavenging free radicals and stimulating anti-oxidant enzymes while acting as regulators for cytokine, protein and adhesion molecule expression, all of which are involved in the atherosclerotic process. Statin use is considered one of the most efficient currently used interventions in managing CVD with the likely hood of remaining so in the near future. Twit Text FOAVip Statins as Pleiotropic Modifiers of Vascular Oxidative Stress and Inflammation ????J Crit Care Med (Targu Mures) http://www.kidney.de/pget.php?&tw=1&pmid=29967815 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29967815 #FOAvip English Wikipedia <ref>{{Cite pmid|29967815}}</ref> Statins as Pleiotropic Modifiers of Vascular Oxidative Stress and Inflammation #MMPMID29967815 Psarros C; Economou EK; Koutsilieris M; Antoniades C J Crit Care Med (Targu Mures) 2015[Apr]; 1 (2): 43-54 PMID29967815show ga Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the industrialized world and in the future is expected to be the number one killer worldwide. The main cause underlying CVD is atherosclerosis. A key event in atherosclerosis initiation and progression is oxidative stress through the production of reactive oxygen species as well as endothelial dysfunction. Several pro- inflammatory and anti-inflammatory cytokines and proteins are involved in this process, complemented by activation of adhesion molecules that promote leukocyte rolling, tethering and infiltration into the sub-endothelial space. Statins represent the agent of choice since numerous clinical trials have verified that their pharmacological action extends beyond lipid lowering. Statins demonstrate direct anti-oxidant effects by scavenging free radicals and stimulating anti-oxidant enzymes while acting as regulators for cytokine, protein and adhesion molecule expression, all of which are involved in the atherosclerotic process. Statin use is considered one of the most efficient currently used interventions in managing CVD with the likely hood of remaining so in the near future. äStatins as Pleiotropic Modifiers of Vascular Oxidative Stress and Infl(epmc).pdf DeepDyve Pubget Overpricing