Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29785112
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Treatment of behavioral and psychological symptoms of dementias with
psychopharmaceuticals: a review
#MMPMID29785112
Masopust J
; Protopopová D
; Vali? M
; Pavelek Z
; Klímová B
Neuropsychiatr Dis Treat
2018[]; 14
(?): 1211-1220
PMID29785112
show ga
Behavioral and psychological symptoms represent common complications in patients
with different types of dementia. Predominantly, they comprise psychosis,
agitation and mood disorders, disinhibited behavior, impairment of the sleep and
wakefulness rhythm, wandering, perseveration, pathological collecting, or
shouting. Their appearance is related to more rapid progression of the disease,
earlier institutionalization, use of physical restraints, and higher risk of
mortality. Consequently, appearance of behavioral and psychological symptoms of
dementia leads to higher costs of care provided and greater distress for
caregivers. Clinical guidelines recommend nonpharmacological approaches as the
first choice in the treatment of behavioral and psychological symptoms.
Pharmacological therapy should be initiated only if the symptoms were not the
result of somatic causes, did not respond to nonpharmacological interventions, or
were not caused by the prior medication. Acetylcholinesterase inhibitors,
memantine, antipsychotic drugs, antidepressants, mood stabilizers, and
benzodiazepines are used. This review summarizes the current findings about the
efficacy and safety of the treatment of the neuropsychiatric symptoms in
dementias with psychopharmaceuticals. Recommendations for treatment with
antipsychotics for this indication are described in detail as this drug group is
prescribed most often and, at the same time, is related to the highest risk of
adverse effects and increased mortality.
free
free
free
