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10.1016/j.redox.2018.03.013

http://scihub22266oqcxt.onion/10.1016/j.redox.2018.03.013
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C5953218!5953218!29597144
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suck abstract from ncbi


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pmid29597144      Redox+Biol 2018 ; 16 (ä): 352-8
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  • Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect #MMPMID29597144
  • Ivanova D; Zhelev Z; Getsov P; Nikolova B; Aoki I; Higashi T; Bakalova R
  • Redox Biol 2018[Jun]; 16 (ä): 352-8 PMID29597144show ga
  • This review is directed to the redox-modulating properties and anticancer effect of vitamin K. The concept is focused on two aspects: (i) redox-cycle of vitamin K and its effect on the calcium homeostasis, ?oncogenic? and ?onco-suppressive? reactive oxygen species and the specific induction of oxidative stress in cancer; (ii) vitamin K plus C as a powerful redox-system, which forms a bypass between mitochondrial complexes II and III and thus prevents mitochondrial dysfunction, restores oxidative phosphorylation and aerobic glycolysis, modulates the redox-state of endogenous redox-pairs, eliminates the hypoxic environment of cancer cells and induces cell death. The analyzed data suggest that vitamin C&K can sensitize cancer cells to conventional chemotherapy, which allows achievement of a lower effective dose of the drug and minimizing the harmful side-effects. The review is intended for a wide audience of readers - from students to specialists in the field.
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