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10.1126/scitranslmed.aam7964 http://scihub22266oqcxt.onion/10.1126/scitranslmed.aam7964 C5953194!5953194!29343625     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Sci+Transl+Med 2018 ; 10 (424): ä Nephropedia Template TP {{tp|p=29343625|t=2018. Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction |pdf=|usr=}}{{29343625}} gab.com Text Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=29343625 #FOAvip Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of morbidity and mortality worldwide and is a frequent cause of skin and soft tissue infections (SSTIs). Lymphedema?fluid accumulation in tissue caused by impaired lymphatic vessel function?is a strong risk factor for SSTIs. SSTIs also frequently recur in patients and sometimes lead to acquired lymphedema. However, the mechanism of how SSTIs can be both the consequence and cause of lymphatic vessel dysfunction is not known. Intravital imaging in mice revealed both an acute reduction in lymphatic vessel contractility and lymph flow after localized MRSA infection. Moreover, chronic lymphatic impairment is observed long after MRSA is cleared and inflammation is resolved. Associated with decreased collecting lymphatic vessel function was the loss and disorganization of lymphatic muscle cells (LMCs), which are critical for lymphatic contraction. In vitro, incubation of MRSA-conditioned supernatant led to LMC death. Proteomic analysis identified several accessory gene regulator (agr)-controlled MRSA exotoxins that contribute to LMC death. Infection with agr mutant MRSA resulted in sustained lymphatic function compared to animals infected with wild type MRSA. Our findings suggest that agr is a promising target to preserve lymphatic vessel function and promote immunity during SSTIs. Twit Text FOAVip Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=29343625 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29343625 #FOAvip English Wikipedia <ref>{{Cite pmid|29343625}}</ref> Methicillin-resistant Staphylococcus aureus causes sustained collecting lymphatic vessel dysfunction #MMPMID29343625 Jones D; Meijer EF; Blatter C; Liao S; Pereira ER; Bouta EM; Jung K; Chin SM; Huang P; Munn LL; Vakoc BJ; Otto M; Padera TP Sci Transl Med 2018[Jan]; 10 (424): ä PMID29343625show ga Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of morbidity and mortality worldwide and is a frequent cause of skin and soft tissue infections (SSTIs). Lymphedema?fluid accumulation in tissue caused by impaired lymphatic vessel function?is a strong risk factor for SSTIs. SSTIs also frequently recur in patients and sometimes lead to acquired lymphedema. However, the mechanism of how SSTIs can be both the consequence and cause of lymphatic vessel dysfunction is not known. Intravital imaging in mice revealed both an acute reduction in lymphatic vessel contractility and lymph flow after localized MRSA infection. Moreover, chronic lymphatic impairment is observed long after MRSA is cleared and inflammation is resolved. Associated with decreased collecting lymphatic vessel function was the loss and disorganization of lymphatic muscle cells (LMCs), which are critical for lymphatic contraction. In vitro, incubation of MRSA-conditioned supernatant led to LMC death. Proteomic analysis identified several accessory gene regulator (agr)-controlled MRSA exotoxins that contribute to LMC death. Infection with agr mutant MRSA resulted in sustained lymphatic function compared to animals infected with wild type MRSA. Our findings suggest that agr is a promising target to preserve lymphatic vessel function and promote immunity during SSTIs. äMethicillin-resistant Staphylococcus aureus causes sustained collectin(epmc).pdf DeepDyve Pubget Overpricing