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10.1016/j.redox.2018.02.014 http://scihub22266oqcxt.onion/10.1016/j.redox.2018.02.014 C5952874!5952874!29501047     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Redox+Biol 2018 ; 16 (ä): 139-45 Nephropedia Template TP {{tp|p=29501047|t=2018. Simvastatin reduces circulating oxysterol levels in men with hypercholesterolaemia |pdf=|usr=}}{{29501047}} gab.com Text Simvastatin reduces circulating oxysterol levels in men with hypercholesterolaemia JO: Redox Biol http://www.kidney.de/pget.php?&tw=1&pmid=29501047 #FOAvip Oxysterols (OHC) are biologically active cholesterol metabolites circulating in plasma that may be formed enzymatically (e.g. 24S-OHC, 25-OHC and 27-OHC) or by autoxidative mechanisms (e.g. 7-ketocholesterol, 7?-OHC and 25-OHC). Oxysterols are more soluble than cholesterol and are reported to exert inflammatory, cytoprotective and apoptotic effects according to concentration and species. Esterified oxysterols have been analysed in people with dementia and cardiovascular diseases although there is no consistent relationship between oxysterol esters and disease. However, oxysterol esters are held in lipoprotein core and may not relate to the concentration and activity of plasma free oxysterols. Methodological limitations have challenged the analysis of free oxysterols to date.We have developed a fast, sensitive and specific quantitative LC-MS/MS, multiple reaction monitoring (MRM) method to target five oxysterols in human plasma with analyte recoveries between 72% and 82% and sensitivities between 5 and 135?pg/ml. A novel method was used to investigate the hypothesis that simvastatin may reduce the concentrations of specific plasma free oxysterols in hypercholesterolaemia.Twenty healthy male volunteers were recruited (aged 41?63 years); ten were asymptomatic with high plasma cholesterol >?6.5?mM and ten were healthy with normal plasma cholesterol (<?6.5?mM). Simvastatin (40?mg/day) was prescribed to those with hypercholesterolaemia. Plasma samples were taken from both groups at baseline and after three months. Simvastatin reduced plasma cholesterol by ~35% (p?<?0.05) at the end of three months.Oxysterols generated by autoxidation (but not enzymatically) were elevated up to 45 fold in hypercholesterolaemic midlife men. Plasma oxysterols were restored to those of healthy controls after simvastatin intervention suggesting that autoxidation is either prevented by simvastatin directly or that autoxidation is less prevalent when plasma cholesterol concentrations are within the normal range. Twit Text FOAVip Simvastatin reduces circulating oxysterol levels in men with hypercholesterolaemia ????Redox Biol http://www.kidney.de/pget.php?&tw=1&pmid=29501047 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29501047 #FOAvip English Wikipedia <ref>{{Cite pmid|29501047}}</ref> Simvastatin reduces circulating oxysterol levels in men with hypercholesterolaemia #MMPMID29501047 Dias IH; Milic I; Lip GY; Devitt A; Polidori MC; Griffiths HR Redox Biol 2018[Jun]; 16 (ä): 139-45 PMID29501047show ga Oxysterols (OHC) are biologically active cholesterol metabolites circulating in plasma that may be formed enzymatically (e.g. 24S-OHC, 25-OHC and 27-OHC) or by autoxidative mechanisms (e.g. 7-ketocholesterol, 7?-OHC and 25-OHC). Oxysterols are more soluble than cholesterol and are reported to exert inflammatory, cytoprotective and apoptotic effects according to concentration and species. Esterified oxysterols have been analysed in people with dementia and cardiovascular diseases although there is no consistent relationship between oxysterol esters and disease. However, oxysterol esters are held in lipoprotein core and may not relate to the concentration and activity of plasma free oxysterols. Methodological limitations have challenged the analysis of free oxysterols to date.We have developed a fast, sensitive and specific quantitative LC-MS/MS, multiple reaction monitoring (MRM) method to target five oxysterols in human plasma with analyte recoveries between 72% and 82% and sensitivities between 5 and 135?pg/ml. A novel method was used to investigate the hypothesis that simvastatin may reduce the concentrations of specific plasma free oxysterols in hypercholesterolaemia.Twenty healthy male volunteers were recruited (aged 41?63 years); ten were asymptomatic with high plasma cholesterol >?6.5?mM and ten were healthy with normal plasma cholesterol ( äSimvastatin reduces circulating oxysterol levels in men with hyperchol(epmc).pdf DeepDyve Pubget Overpricing