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10.1186/s12882-018-0910-9 http://scihub22266oqcxt.onion/10.1186/s12882-018-0910-9 C5952622!5952622 !29764395     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29764395 &cmd=llinks): Failed to open stream: HTTP request failed! 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Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism |pdf=|usr=}}{{29764395 }} gab.com Text Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism JO: BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=29764395 #FOAvip BACKGROUND: The calcimimetic agent cinacalcet is effective for the management of secondary hyperparathyroidism (SHPT) in dialysis patients. Changes to reimbursement of cinacalcet in Australia provided an opportunity to assess effects of medication cessation on biochemical and clinical outcomes in dialysis patients, including changes to novel biomarkers such as calciprotein particles (CPP). CPP are nanoparticles of mineral and protein in the circulation associated with increased vascular calcification in patients with chronic kidney disease. METHODS: Dialysis patients from a single center who ceased cinacalcet between August 2015 and March 2016 were included in a prospective observational study. Bloods were taken at the time of cessation of cinacalcet and at 1, 6 and 12 months. Clinical and biochemical outcomes were compared with an age- and gender-matched cohort of cinacalcet-naïve dialysis patients. RESULTS: Sixty-two patients participated in the study. Mean age was 69.6?±?13.2 years. Biochemical changes over 12 months following cessation of cinacalcet included an increase in serum parathyroid hormone (PTH) (42.2 [IQR 27.8-94.6] pmol/L to 114.8 [83.9-159.1] pmol/L [p?<?0.001]), serum calcium (2.31?±?0.21 mmol/L to 2.46?±?0.14 mmol/L [p?<?0.001]) and primary CPP (CPP-I) (p?=?0.002). Changes in CPP were associated with an increase in PTH (p?=?0.007), calcium (p?=?0.002) and ferritin (p?=?0.02) but a reduction in serum albumin (p?=?0.001). Over the 12-month period, there were two fractures, five cardiovascular events, one episode of calciphylaxis, and one parathyroidectomy, with a mortality rate of 19% (n?=?13). CONCLUSION: Uniquely we report the effects of cinacalcet withdrawal in a real world setting with demonstrated increases in PTH, serum calcium and CPP subsets, novel CKD-MBD related factors, over a 12-month period. Twit Text FOAVip Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism ????BMC Nephrol http://www.kidney.de/pget.php?&tw=1&pmid=29764395 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29764395 #FOAvip English Wikipedia <ref>{{Cite pmid|29764395 }}</ref> Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism #MMPMID29764395 Ruderman I ; Smith ER ; Toussaint ND ; Hewitson TD ; Holt SG BMC Nephrol 2018[May]; 19 (1 ): 113 PMID29764395 show ga BACKGROUND: The calcimimetic agent cinacalcet is effective for the management of secondary hyperparathyroidism (SHPT) in dialysis patients. Changes to reimbursement of cinacalcet in Australia provided an opportunity to assess effects of medication cessation on biochemical and clinical outcomes in dialysis patients, including changes to novel biomarkers such as calciprotein particles (CPP). CPP are nanoparticles of mineral and protein in the circulation associated with increased vascular calcification in patients with chronic kidney disease. METHODS: Dialysis patients from a single center who ceased cinacalcet between August 2015 and March 2016 were included in a prospective observational study. Bloods were taken at the time of cessation of cinacalcet and at 1, 6 and 12 months. Clinical and biochemical outcomes were compared with an age- and gender-matched cohort of cinacalcet-naïve dialysis patients. RESULTS: Sixty-two patients participated in the study. Mean age was 69.6?±?13.2 years. Biochemical changes over 12 months following cessation of cinacalcet included an increase in serum parathyroid hormone (PTH) (42.2 [IQR 27.8-94.6] pmol/L to 114.8 [83.9-159.1] pmol/L [p? |Aged [MESH] |Aged, 80 and over [MESH] |Biomarkers/blood [MESH] |Bone Density/drug effects/*physiology [MESH] |Calcimimetic Agents/*administration & dosage [MESH] |Calcium/blood [MESH] |Cinacalcet/*administration & dosage [MESH] |Cohort Studies [MESH] |Female [MESH] |Humans [MESH] |Hyperparathyroidism, Secondary/*blood/diagnosis/therapy [MESH] |Longitudinal Studies [MESH] |Male [MESH] |Middle Aged [MESH] |Parathyroid Hormone/blood [MESH] |Prospective Studies [MESH] |Renal Dialysis/adverse effects/*trends [MESH]Longitudinal changes in bone and mineral metabolism after cessation of(epmc).pdf DeepDyve Pubget Overpricing