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2018 ; 44
(1
): 55
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Inhaled nitric oxide as a rescue therapy in a preterm neonate with severe
pulmonary hypertension: a case report
#MMPMID29764471
Busč M
; Graziano F
; Lunetta F
; Sulliotti G
; Duca V
Ital J Pediatr
2018[May]; 44
(1
): 55
PMID29764471
show ga
BACKGROUND: Inhaled nitric oxide (iNO) has been approved for the treatment of
persistent pulmonary hypertension of the newborn (PPHN) in term and near-term
newborns. Its role in the management of persistent pulmonary hypertension in
preterm infants is not clear. Although guidelines do not exist, some studies have
shown that iNO could be used as a rescue therapy in preterm neonate with severe
pulmonary hypertension. CASE PRESENTATION: We describe the case of a preterm
neonate, born at 30?+?1 weeks of gestation, with hypoxic respiratory failure not
responding to maximal conventional therapy. On the third day of life
echocardiography showed severe pulmonary hypertension with right to left shunt
and therapy with iNO was started. We achieved a rapid improvement in clinical
conditions and pulmonary pressure normalized after 42 h of treatment.
CONCLUSIONS: Moving on a case by case basis, treatment with iNO should be
considered as a rescue therapy in preterm newborns with acute hypoxic respiratory
failure caused by severe pulmonary hypertension.