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http://scihub22266oqcxt.onion/ C5952201!5952201 !1668145     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=1668145 &cmd=llinks): Failed to open stream: HTTP request failed! 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Every enhancer works with every promoter for all the combinations tested: could new regulatory pathways evolve by enhancer shuffling? |pdf=|usr=}}{{1668145 }} gab.com Text Every enhancer works with every promoter for all the combinations tested: could new regulatory pathways evolve by enhancer shuffling JO: Gene Expr http://www.kidney.de/pget.php?&tw=1&pmid=1668145 #FOAvip The promoters and enhancers of cell type-specific genes are often conserved in evolution, and hence one might expect that a given enhancer has evolved to work best with its own promoter. While this expectation may be realized in some cases, we have not found evidence for it. A total of 27 combinations of different promoters and enhancers were tested by transfection into cultured cells. We found that the relative efficiency of the enhancers is approximately the same, irrespective of the type of promoter used, i.e., there was no strong preference for any given enhancer/promoter combination. Notably, we do not see particularly strong transcription when the immunoglobulin kappa enhancer (or the immunoglobulin heavy chain enhancer) is used to activate a kappa gene promoter. We propose that a generally permissive enhancer/promoter interaction is of evolutionary benefit for higher eukaryotes: by enhancer shuffling, genes could be easily brought under a new type of inducibility/cell type specificity. Twit Text FOAVip Every enhancer works with every promoter for all the combinations tested: could new regulatory pathways evolve by enhancer shuffling ????Gene Expr http://www.kidney.de/pget.php?&tw=1&pmid=1668145 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=1668145 #FOAvip English Wikipedia <ref>{{Cite pmid|1668145 }}</ref> Every enhancer works with every promoter for all the combinations tested: could new regulatory pathways evolve by enhancer shuffling? #MMPMID1668145 Kermekchiev M ; Pettersson M ; Matthias P ; Schaffner W Gene Expr 1991[Apr]; 1 (1 ): 71-81 PMID1668145 show ga The promoters and enhancers of cell type-specific genes are often conserved in evolution, and hence one might expect that a given enhancer has evolved to work best with its own promoter. While this expectation may be realized in some cases, we have not found evidence for it. A total of 27 combinations of different promoters and enhancers were tested by transfection into cultured cells. We found that the relative efficiency of the enhancers is approximately the same, irrespective of the type of promoter used, i.e., there was no strong preference for any given enhancer/promoter combination. Notably, we do not see particularly strong transcription when the immunoglobulin kappa enhancer (or the immunoglobulin heavy chain enhancer) is used to activate a kappa gene promoter. We propose that a generally permissive enhancer/promoter interaction is of evolutionary benefit for higher eukaryotes: by enhancer shuffling, genes could be easily brought under a new type of inducibility/cell type specificity. |B-Lymphocytes/metabolism [MESH] |Base Sequence [MESH] |Cell Line [MESH] |DNA, Recombinant [MESH] |Enhancer Elements, Genetic/*physiology [MESH] |Genes, Synthetic [MESH] |Humans [MESH] |Immunoglobulin kappa-Chains/genetics [MESH] |Molecular Sequence Data [MESH] |NF-kappa B/metabolism [MESH] |Promoter Regions, Genetic/*physiology [MESH] |Simian virus 40/genetics [MESH] |Transcription, Genetic/*genetics [MESH]Every enhancer works with every promoter for all the combinations test(epmc).pdf DeepDyve Pubget Overpricing