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10.1109/BIBM.2016.7822490 http://scihub22266oqcxt.onion/10.1109/BIBM.2016.7822490 C5952046!5952046 !29770260     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29770260 &cmd=llinks): Failed to open stream: HTTP request failed! 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Deep Convolutional Neural Networks for Detecting Secondary Structures in Protein Density Maps from Cryo-Electron Microscopy |pdf=|usr=}}{{29770260 }} gab.com Text Deep Convolutional Neural Networks for Detecting Secondary Structures in Protein Density Maps from Cryo-Electron Microscopy JO: Proceedings (IEEE Int Conf Bioinformatics Biomed) http://www.kidney.de/pget.php?&tw=1&pmid=29770260 #FOAvip The detection of secondary structure of proteins using three dimensional (3D) cryo-electron microscopy (cryo-EM) images is still a challenging task when the spatial resolution of cryo-EM images is at medium level (5-10Å ). Prior researches focused on the usage of local features that may not capture the global information of image objects. In this study, we propose to use deep learning methods to extract high representative global features and then automatically detect secondary structures of proteins. In particular, we build a convolutional neural network (CNN) classifier that predicts the probability of label for every individual voxel in 3D cryo-EM image with respect to the secondary structure elements of proteins such as ?-helix, ?-sheet and background. To effectively incorporate the 3D spatial information in protein structures, we propose to perform 3D convolutions in the convolutional layers of CNNs. We show that the proposed CNN classifier can outperform existing SVM method on identifying the secondary structure elements of proteins from 3D cryo-EM medium resolution images. Twit Text FOAVip Deep Convolutional Neural Networks for Detecting Secondary Structures in Protein Density Maps from Cryo-Electron Microscopy ????Proceedings (IEEE Int Conf Bioinformatics Biomed) http://www.kidney.de/pget.php?&tw=1&pmid=29770260 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29770260 #FOAvip English Wikipedia <ref>{{Cite pmid|29770260 }}</ref> Deep Convolutional Neural Networks for Detecting Secondary Structures in Protein Density Maps from Cryo-Electron Microscopy #MMPMID29770260 Li R ; Si D ; Zeng T ; Ji S ; He J Proceedings (IEEE Int Conf Bioinformatics Biomed) 2016[Dec]; 2016 (ä): 41-46 PMID29770260 show ga The detection of secondary structure of proteins using three dimensional (3D) cryo-electron microscopy (cryo-EM) images is still a challenging task when the spatial resolution of cryo-EM images is at medium level (5-10Å ). Prior researches focused on the usage of local features that may not capture the global information of image objects. In this study, we propose to use deep learning methods to extract high representative global features and then automatically detect secondary structures of proteins. In particular, we build a convolutional neural network (CNN) classifier that predicts the probability of label for every individual voxel in 3D cryo-EM image with respect to the secondary structure elements of proteins such as ?-helix, ?-sheet and background. To effectively incorporate the 3D spatial information in protein structures, we propose to perform 3D convolutions in the convolutional layers of CNNs. We show that the proposed CNN classifier can outperform existing SVM method on identifying the secondary structure elements of proteins from 3D cryo-EM medium resolution images. äDeep Convolutional Neural Networks for Detecting Secondary Structures (epmc).pdf DeepDyve Pubget Overpricing