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10.1016/j.semcdb.2016.06.012 http://scihub22266oqcxt.onion/10.1016/j.semcdb.2016.06.012 C5951171!5951171 !27338857     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27338857 &cmd=llinks): Failed to open stream: HTTP request failed! 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The value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancers |pdf=|usr=}}{{27338857 }} gab.com Text The value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancers JO: Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=27338857 #FOAvip The rise in genomic knowledge over the past decade has revealed the molecular etiology of many diseases, and has identified intricate signaling network activity in human cancers. Genomics provides the opportunity to determine genome structure and capture the activity of thousands of molecular events concurrently, which is important for deciphering highly complex genetic diseases such as cancer. In this review, we focus on genomic efforts directed towards one of cancer's most frequently mutated networks, the RAS pathway. Genomic tools such as gene expression signatures and assessment of mutations across the RAS network enable the capture of RAS signaling complexity. Due to this high level of interaction and cross-talk within the network, efforts to target RAS signaling in the clinic have generally failed, and we currently lack the ability to directly inhibit the RAS protein with high efficacy. We propose that the use of gene expression data can identify effective treatments that broadly inhibit the RAS network as this approach measures pathway activity independent of mutation status or any single mechanism of activation. Here, we review the genomic studies that map the complexity of the RAS network in cancer, and that show how genomic measurements of RAS pathway activation can identify effective RAS inhibition strategies. We also address the challenges and future directions for treating RAS-driven tumors. In summary, genomic assessment of RAS signaling provides a level of complexity necessary to accurately map the network that matches the intricacy of RAS pathway interactions in cancer. Twit Text FOAVip The value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancers ????Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=27338857 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27338857 #FOAvip English Wikipedia <ref>{{Cite pmid|27338857 }}</ref> The value of genomics in dissecting the RAS-network and in guiding therapeutics for RAS-driven cancers #MMPMID27338857 Shrestha G ; MacNeil SM ; McQuerry JA ; Jenkins DF ; Sharma S ; Bild AH Semin Cell Dev Biol 2016[Oct]; 58 (ä): 108-17 PMID27338857 show ga The rise in genomic knowledge over the past decade has revealed the molecular etiology of many diseases, and has identified intricate signaling network activity in human cancers. Genomics provides the opportunity to determine genome structure and capture the activity of thousands of molecular events concurrently, which is important for deciphering highly complex genetic diseases such as cancer. In this review, we focus on genomic efforts directed towards one of cancer's most frequently mutated networks, the RAS pathway. Genomic tools such as gene expression signatures and assessment of mutations across the RAS network enable the capture of RAS signaling complexity. Due to this high level of interaction and cross-talk within the network, efforts to target RAS signaling in the clinic have generally failed, and we currently lack the ability to directly inhibit the RAS protein with high efficacy. We propose that the use of gene expression data can identify effective treatments that broadly inhibit the RAS network as this approach measures pathway activity independent of mutation status or any single mechanism of activation. Here, we review the genomic studies that map the complexity of the RAS network in cancer, and that show how genomic measurements of RAS pathway activation can identify effective RAS inhibition strategies. We also address the challenges and future directions for treating RAS-driven tumors. In summary, genomic assessment of RAS signaling provides a level of complexity necessary to accurately map the network that matches the intricacy of RAS pathway interactions in cancer. |*Genomics [MESH] |*Molecular Targeted Therapy [MESH] |Animals [MESH] |Humans [MESH] |Models, Biological [MESH] |Neoplasms/genetics/*metabolism/pathology/*therapy [MESH] |Signal Transduction [MESH]The value of genomics in dissecting the RAS-network and in guiding the(epmc).pdf DeepDyve Pubget Overpricing