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10.1177/1932296817699639 http://scihub22266oqcxt.onion/10.1177/1932296817699639 C5950988!5950988!28299957     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Diabetes+Sci+Technol 2017 ; 11 (5): 930-5 Nephropedia Template TP {{tp|p=28299957|t=2017. Enhancing Glycemic Control via Detection of Insulin Using Electrochemical Impedance Spectroscopy |pdf=|usr=}}{{28299957}} gab.com Text Enhancing Glycemic Control via Detection of Insulin Using Electrochemical Impedance Spectroscopy JO: J Diabetes Sci Technol http://www.kidney.de/pget.php?&tw=1&pmid=28299957 #FOAvip Background:: Currently, glycemic management for individuals with diabetes mellitus involves monitoring glucose only, which is insufficient as glucose metabolism involves other biomarkers such as insulin. Monitoring additional biomarkers alongside glucose has been proposed to improve glycemic control. In this work, the development of a rapid and label-free insulin biosensor with high sensitivity and accuracy is presented. The insulin sensor prototype also serves as a prior study for a multimarker sensing platform technology that can further improve glycemic control in the future. Methods:: Electrochemical impedance spectroscopy was used to identify an optimal frequency specific to insulin detection on a gold disk electrode with insulin antibody immobilized, which was accomplished by conjugating the primary amines of insulin antibody to the carboxylic bond of the self-assembling monolayer on the gold surface. After blocking with ethanolamine, the insulin physiological concentration gradient was tested. The imaginary impedance was correlated to insulin concentration and the results were compared with standard equivalent circuit analysis and correlation of charge transfer resistance to target concentration. Results:: The optimal frequency of insulin is 810.5 Hz, which is characterized by having the highest sensitivity and sufficient specificity. The lower limit of detection was 2.26 ?M which is comparable to a standard and better than traditional approaches. Conclusion:: An insulin biosensor prototype capable of detecting insulin in physiological range without complex data normalization was developed. This prototype will be the ground works of a multimarker platform sensor technology for future all-in-one glycemic management sensors. Twit Text FOAVip Enhancing Glycemic Control via Detection of Insulin Using Electrochemical Impedance Spectroscopy ????J Diabetes Sci Technol http://www.kidney.de/pget.php?&tw=1&pmid=28299957 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28299957 #FOAvip English Wikipedia <ref>{{Cite pmid|28299957}}</ref> Enhancing Glycemic Control via Detection of Insulin Using Electrochemical Impedance Spectroscopy #MMPMID28299957 Malkoc A; Probst D; Lin C; Khanwalker M; Beck C; Cook CB; La Belle JT J Diabetes Sci Technol 2017[Sep]; 11 (5): 930-5 PMID28299957show ga Background:: Currently, glycemic management for individuals with diabetes mellitus involves monitoring glucose only, which is insufficient as glucose metabolism involves other biomarkers such as insulin. Monitoring additional biomarkers alongside glucose has been proposed to improve glycemic control. In this work, the development of a rapid and label-free insulin biosensor with high sensitivity and accuracy is presented. The insulin sensor prototype also serves as a prior study for a multimarker sensing platform technology that can further improve glycemic control in the future. Methods:: Electrochemical impedance spectroscopy was used to identify an optimal frequency specific to insulin detection on a gold disk electrode with insulin antibody immobilized, which was accomplished by conjugating the primary amines of insulin antibody to the carboxylic bond of the self-assembling monolayer on the gold surface. After blocking with ethanolamine, the insulin physiological concentration gradient was tested. The imaginary impedance was correlated to insulin concentration and the results were compared with standard equivalent circuit analysis and correlation of charge transfer resistance to target concentration. Results:: The optimal frequency of insulin is 810.5 Hz, which is characterized by having the highest sensitivity and sufficient specificity. The lower limit of detection was 2.26 ?M which is comparable to a standard and better than traditional approaches. Conclusion:: An insulin biosensor prototype capable of detecting insulin in physiological range without complex data normalization was developed. This prototype will be the ground works of a multimarker platform sensor technology for future all-in-one glycemic management sensors. äEnhancing Glycemic Control via Detection of Insulin Using Electrochemi(epmc).pdf DeepDyve Pubget Overpricing