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10.3892/ol.2018.8378

http://scihub22266oqcxt.onion/10.3892/ol.2018.8378
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C5950136!5950136!29805553
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suck abstract from ncbi

pmid29805553      Oncol+Lett 2018 ; 15 (6): 8187-94
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  • Recent advances in CD8+ regulatory T cell research #MMPMID29805553
  • Yu Y; Ma X; Gong R; Zhu J; Wei L; Yao J
  • Oncol Lett 2018[Jun]; 15 (6): 8187-94 PMID29805553show ga
  • Various subgroups of CD8+ T lymphocytes do not only demonstrate cytotoxic effects, but also serve important regulatory roles in the body's immune response. In particular, CD8+ regulatory T cells (CD8+ Tregs), which possess important immunosuppressive functions, are able to effectively block the overreacting immune response and maintain the body's immune homeostasis. In recent years, studies have identified a small set of special CD8+ Tregs that can recognize major histocompatibility complex class Ib molecules, more specifically Qa-1 in mice and HLA-E in humans, and target the self-reactive CD4+ T ce lls. These findings have generated broad implications in the scientific community and attracted general interest to CD8+ Tregs. The present study reviews the recent research progress on CD8+ Tregs, including their origin, functional classification, molecular markers and underlying mechanisms of action.
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