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10.1073/pnas.1802893115 http://scihub22266oqcxt.onion/10.1073/pnas.1802893115 C5949009!5949009!29674451     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (19): E4463-72 Nephropedia Template TP {{tp|p=29674451|t=2018. Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert |pdf=|usr=}}{{29674451}} gab.com Text Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29674451 #FOAvip While stem cell therapy has become the standard of care for hematological disorders, challenges remain for the treatment of solid organ injuries. Targeting endogenous cells would overcome many hurdles associated with exogenous stem cell therapy. Alarmins are released upon tissue damage, and here we describe how upregulation of a physiological pathway by exogenous administration of a single dose of HMGB1, either locally or systemically, promotes tissue repair by targeting endogenous stem cells. We show that HMGB1 complexed with CXCL12 transitions stem cells that express CXCR4 from G0 to GAlert. These primed cells rapidly respond to appropriate activating factors released upon injury. HMGB1 promotes healing even if administered 2 wk before injury, thereby expanding its translational benefit for diverse clinical scenarios. Twit Text FOAVip Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29674451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29674451 #FOAvip English Wikipedia <ref>{{Cite pmid|29674451}}</ref> Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to GAlert #MMPMID29674451 Lee G; Espirito Santo AI; Zwingenberger S; Cai L; Vogl T; Feldmann M; Horwood NJ; Chan JK; Nanchahal J Proc Natl Acad Sci U S A 2018[May]; 115 (19): E4463-72 PMID29674451show ga While stem cell therapy has become the standard of care for hematological disorders, challenges remain for the treatment of solid organ injuries. Targeting endogenous cells would overcome many hurdles associated with exogenous stem cell therapy. Alarmins are released upon tissue damage, and here we describe how upregulation of a physiological pathway by exogenous administration of a single dose of HMGB1, either locally or systemically, promotes tissue repair by targeting endogenous stem cells. We show that HMGB1 complexed with CXCL12 transitions stem cells that express CXCR4 from G0 to GAlert. These primed cells rapidly respond to appropriate activating factors released upon injury. HMGB1 promotes healing even if administered 2 wk before injury, thereby expanding its translational benefit for diverse clinical scenarios. äFully reduced HMGB1 accelerates the regeneration of multiple tissues b(epmc).pdf DeepDyve Pubget Overpricing