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10.1073/pnas.1802893115 http://scihub22266oqcxt.onion/10.1073/pnas.1802893115 C5949009!5949009 !29674451     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29674451 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (19 ): E4463-E4472 Nephropedia Template TP {{tp|p=29674451 |t=2018. Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to G(Alert) |pdf=|usr=}}{{29674451 }} gab.com Text Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to G(Alert) JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29674451 #FOAvip A major discovery of recent decades has been the existence of stem cells and their potential to repair many, if not most, tissues. With the aging population, many attempts have been made to use exogenous stem cells to promote tissue repair, so far with limited success. An alternative approach, which may be more effective and far less costly, is to promote tissue regeneration by targeting endogenous stem cells. However, ways of enhancing endogenous stem cell function remain poorly defined. Injury leads to the release of danger signals which are known to modulate the immune response, but their role in stem cell-mediated repair in vivo remains to be clarified. Here we show that high mobility group box 1 (HMGB1) is released following fracture in both humans and mice, forms a heterocomplex with CXCL12, and acts via CXCR4 to accelerate skeletal, hematopoietic, and muscle regeneration in vivo. Pretreatment with HMGB1 2 wk before injury also accelerated tissue regeneration, indicating an acquired proregenerative signature. HMGB1 led to sustained increase in cell cycling in vivo, and using Hmgb1(-/-) mice we identified the underlying mechanism as the transition of multiple quiescent stem cells from G(0) to G(Alert) HMGB1 also transitions human stem and progenitor cells to G(Alert) Therefore, exogenous HMGB1 may benefit patients in many clinical scenarios, including trauma, chemotherapy, and elective surgery. Twit Text FOAVip Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to G(Alert) ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29674451 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29674451 #FOAvip English Wikipedia <ref>{{Cite pmid|29674451 }}</ref> Fully reduced HMGB1 accelerates the regeneration of multiple tissues by transitioning stem cells to G(Alert) #MMPMID29674451 Lee G ; Espirito Santo AI ; Zwingenberger S ; Cai L ; Vogl T ; Feldmann M ; Horwood NJ ; Chan JK ; Nanchahal J Proc Natl Acad Sci U S A 2018[May]; 115 (19 ): E4463-E4472 PMID29674451 show ga A major discovery of recent decades has been the existence of stem cells and their potential to repair many, if not most, tissues. With the aging population, many attempts have been made to use exogenous stem cells to promote tissue repair, so far with limited success. An alternative approach, which may be more effective and far less costly, is to promote tissue regeneration by targeting endogenous stem cells. However, ways of enhancing endogenous stem cell function remain poorly defined. Injury leads to the release of danger signals which are known to modulate the immune response, but their role in stem cell-mediated repair in vivo remains to be clarified. Here we show that high mobility group box 1 (HMGB1) is released following fracture in both humans and mice, forms a heterocomplex with CXCL12, and acts via CXCR4 to accelerate skeletal, hematopoietic, and muscle regeneration in vivo. Pretreatment with HMGB1 2 wk before injury also accelerated tissue regeneration, indicating an acquired proregenerative signature. HMGB1 led to sustained increase in cell cycling in vivo, and using Hmgb1(-/-) mice we identified the underlying mechanism as the transition of multiple quiescent stem cells from G(0) to G(Alert) HMGB1 also transitions human stem and progenitor cells to G(Alert) Therefore, exogenous HMGB1 may benefit patients in many clinical scenarios, including trauma, chemotherapy, and elective surgery. |*Cell Cycle [MESH] |*Regeneration [MESH] |Animals [MESH] |Cells, Cultured [MESH] |Chemokine CXCL12/metabolism [MESH] |Fractures, Bone/*therapy [MESH] |HMGB1 Protein/*physiology [MESH] |Hematopoietic Stem Cells/*cytology/physiology [MESH] |Humans [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Muscle, Skeletal/*cytology/physiology [MESH] |Osteogenesis [MESH] |Receptors, CXCR4/metabolism [MESH] |Signal Transduction [MESH]Fully reduced HMGB1 accelerates the regeneration of multiple tissues b(epmc).pdf DeepDyve Pubget Overpricing