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10.1186/s12943-018-0839-4 http://scihub22266oqcxt.onion/10.1186/s12943-018-0839-4 C5948872!5948872!29753331     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mol+Cancer 2018 ; 17 (ä): ä Nephropedia Template TP {{tp|p=29753331|t=2018. Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer |pdf=|usr=}}{{29753331}} gab.com Text Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer JO: Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29753331 #FOAvip TIGAR is a p53 target gene that is known to protect cells from ROS-induced apoptosis by promoting the pentose phosphate pathway. The role of TIGAR in tumor cell invasion and metastasis remains elusive. Here we found that downregulation of TIGAR reduced the invasion and metastasis of NSCLC cells in vitro and in vivo. Immunohistochemical analysis of 72 NSCLC patients showed that TIGAR and Met protein expression was positively correlated with late stages of lung cancer. Besides, patients with high co-expression of TIGAR and Met presented a significantly worse survival. In addition, we found that Met signaling pathway is involved in TIGAR-induced invasion and metastasis. Our study indicates that TIGAR/Met pathway may be a novel target for NSCLC therapy. It is necessary to evaluate the expression of TIGAR before Met inhibitors are used for NSCLC treatment.Electronic supplementary material: The online version of this article (10.1186/s12943-018-0839-4) contains supplementary material, which is available to authorized users. Twit Text FOAVip Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer ????Mol Cancer http://www.kidney.de/pget.php?&tw=1&pmid=29753331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29753331 #FOAvip English Wikipedia <ref>{{Cite pmid|29753331}}</ref> Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer #MMPMID29753331 Shen M; Zhao X; Zhao L; Shi L; An S; Huang G; Liu J Mol Cancer 2018[]; 17 (ä): ä PMID29753331show ga TIGAR is a p53 target gene that is known to protect cells from ROS-induced apoptosis by promoting the pentose phosphate pathway. The role of TIGAR in tumor cell invasion and metastasis remains elusive. Here we found that downregulation of TIGAR reduced the invasion and metastasis of NSCLC cells in vitro and in vivo. Immunohistochemical analysis of 72 NSCLC patients showed that TIGAR and Met protein expression was positively correlated with late stages of lung cancer. Besides, patients with high co-expression of TIGAR and Met presented a significantly worse survival. In addition, we found that Met signaling pathway is involved in TIGAR-induced invasion and metastasis. Our study indicates that TIGAR/Met pathway may be a novel target for NSCLC therapy. It is necessary to evaluate the expression of TIGAR before Met inhibitors are used for NSCLC treatment.Electronic supplementary material: The online version of this article (10.1186/s12943-018-0839-4) contains supplementary material, which is available to authorized users. äMet is involved in TIGAR-regulated metastasis of non-small-cell lung c(epmc).pdf DeepDyve Pubget Overpricing