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10.1007/s00018-018-2794-z http://scihub22266oqcxt.onion/10.1007/s00018-018-2794-z C5948302!5948302!29541793     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Mol+Life+Sci 2018 ; 75 (12): 2177-95 Nephropedia Template TP {{tp|p=29541793|t=2018. Nestin-expressing progenitor cells: function, identity and therapeutic implications |pdf=|usr=}}{{29541793}} gab.com Text Nestin-expressing progenitor cells: function, identity and therapeutic implications JO: Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=29541793 #FOAvip The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cells with progenitor and/or regulatory functions in a number of additional tissues, remarkably bone marrow. This review presents the current knowledge on the role of Nestin in essential stem cell functions, including self-renewal/proliferation, differentiation and migration, in the context of the cytoskeleton. We further discuss the available in vivo models for the study of Nestin+ cells and their progeny, their function and elusive nature in nervous system and bone marrow, and their potential mechanistic role and promising therapeutic value in preclinical models of disease. Future improved in vivo models and detection methods will allow to determine the true essence of Nestin+ cells and confirm their potential application as therapeutic target in a range of diseases. Twit Text FOAVip Nestin-expressing progenitor cells: function, identity and therapeutic implications ????Cell Mol Life Sci http://www.kidney.de/pget.php?&tw=1&pmid=29541793 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29541793 #FOAvip English Wikipedia <ref>{{Cite pmid|29541793}}</ref> Nestin-expressing progenitor cells: function, identity and therapeutic implications #MMPMID29541793 Bernal A; Arranz L Cell Mol Life Sci 2018[]; 75 (12): 2177-95 PMID29541793show ga The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament initially characterized in neural stem cells. However, current extensive evidence obtained in in vivo models and humans shows presence of Nestin+ cells with progenitor and/or regulatory functions in a number of additional tissues, remarkably bone marrow. This review presents the current knowledge on the role of Nestin in essential stem cell functions, including self-renewal/proliferation, differentiation and migration, in the context of the cytoskeleton. We further discuss the available in vivo models for the study of Nestin+ cells and their progeny, their function and elusive nature in nervous system and bone marrow, and their potential mechanistic role and promising therapeutic value in preclinical models of disease. Future improved in vivo models and detection methods will allow to determine the true essence of Nestin+ cells and confirm their potential application as therapeutic target in a range of diseases. äNestin-expressing progenitor cells: function, identity and therapeutic(epmc).pdf DeepDyve Pubget Overpricing