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10.1007/s00018-018-2784-1

http://scihub22266oqcxt.onion/10.1007/s00018-018-2784-1
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C5948278!5948278!29502308
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suck abstract from ncbi


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pmid29502308      Cell+Mol+Life+Sci 2018 ; 75 (12): 2093-109
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  • Biochemistry of proinflammatory macrophage activation #MMPMID29502308
  • Nonnenmacher Y; Hiller K
  • Cell Mol Life Sci 2018[]; 75 (12): 2093-109 PMID29502308show ga
  • In the last decade, metabolism has been recognized as a major determinant of immunological processes. During an inflammatory response, macrophages undergo striking changes in their metabolism. This metabolic reprogramming is governed by a complex interplay between metabolic enzymes and metabolites of different pathways and represents the basis for proper macrophage function. It is now evident that these changes go far beyond the well-known Warburg effect and the perturbation of metabolic targets is being investigated as a means to treat infections and auto-immune diseases. In the present review, we will aim to provide an overview of the metabolic responses during proinflammatory macrophage activation and show how these changes modulate the immune response.
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