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10.1016/j.cbpa.2016.12.011 http://scihub22266oqcxt.onion/10.1016/j.cbpa.2016.12.011 C5947866!5947866!28040658     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Curr+Opin+Chem+Biol 2017 ; 37 (ä): 26-32 Nephropedia Template TP {{tp|p=28040658|t=2017. Developing drugs targeting transition metal homeostasis |pdf=|usr=}}{{28040658}} gab.com Text Developing drugs targeting transition metal homeostasis JO: Curr Opin Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28040658 #FOAvip Metal dyshomeostasis is involved in the pathogenesis and progression of diseases including cancer and neurodegenerative diseases. Metal chelators and ionophores are well known modulators of transition metal homeostasis, and a number of these molecules are in clinical trials. Metalbinding compounds are not the only drugs capable of targeting transition metal homeostasis. This review presents recent highlights in the development of chelators and ionophores for the treatment of cancer and neurodegenerative disease. Moreover, we discuss the development of small molecules that alter copper and iron homeostasis by inhibiting metal transport proteins. Finally, we consider the emergence of metal regulatory factor 1 as a drug target in diseases where it mediates zinc-induced signalling cascades leading to pathogenesis. Twit Text FOAVip Developing drugs targeting transition metal homeostasis ????Curr Opin Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28040658 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28040658 #FOAvip English Wikipedia <ref>{{Cite pmid|28040658}}</ref> Developing drugs targeting transition metal homeostasis #MMPMID28040658 Weekley CM; He C Curr Opin Chem Biol 2017[Apr]; 37 (ä): 26-32 PMID28040658show ga Metal dyshomeostasis is involved in the pathogenesis and progression of diseases including cancer and neurodegenerative diseases. Metal chelators and ionophores are well known modulators of transition metal homeostasis, and a number of these molecules are in clinical trials. Metalbinding compounds are not the only drugs capable of targeting transition metal homeostasis. This review presents recent highlights in the development of chelators and ionophores for the treatment of cancer and neurodegenerative disease. Moreover, we discuss the development of small molecules that alter copper and iron homeostasis by inhibiting metal transport proteins. Finally, we consider the emergence of metal regulatory factor 1 as a drug target in diseases where it mediates zinc-induced signalling cascades leading to pathogenesis. äDeveloping drugs targeting transition metal homeostasis (epmc).pdf DeepDyve Pubget Overpricing