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10.1107/S2052252518001616 http://scihub22266oqcxt.onion/10.1107/S2052252518001616 C5947725!5947725 !29765610     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29765610 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       IUCrJ 2018 ; 5 (Pt 2 ): 200-210 Nephropedia Template TP {{tp|p=29765610 |t=2018. X-ray and cryo-EM structures of inhibitor-bound cytochrome bc(1) complexes for structure-based drug discovery |pdf=|usr=}}{{29765610 }} gab.com Text X-ray and cryo-EM structures of inhibitor-bound cytochrome bc(1) complexes for structure-based drug discovery JO: IUCrJ http://www.kidney.de/pget.php?&tw=1&pmid=29765610 #FOAvip Cytochrome bc(1), a dimeric multi-subunit electron-transport protein embedded in the inner mitochondrial membrane, is a major drug target for the treatment and prevention of malaria and toxoplasmosis. Structural studies of cytochrome bc(1) from mammalian homologues co-crystallized with lead compounds have underpinned structure-based drug design to develop compounds with higher potency and selectivity. However, owing to the limited amount of cytochrome bc(1) that may be available from parasites, all efforts have been focused on homologous cytochrome bc(1) complexes from mammalian species, which has resulted in the failure of some drug candidates owing to toxicity in the host. Crystallographic studies of the native parasite proteins are not feasible owing to limited availability of the proteins. Here, it is demonstrated that cytochrome bc(1) is highly amenable to single-particle cryo-EM (which uses significantly less protein) by solving the apo and two inhibitor-bound structures to ?4.1?Å resolution, revealing clear inhibitor density at the binding site. Therefore, cryo-EM is proposed as a viable alternative method for structure-based drug discovery using both host and parasite enzymes. Twit Text FOAVip X-ray and cryo-EM structures of inhibitor-bound cytochrome bc(1) complexes for structure-based drug discovery ????IUCrJ http://www.kidney.de/pget.php?&tw=1&pmid=29765610 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29765610 #FOAvip English Wikipedia <ref>{{Cite pmid|29765610 }}</ref> X-ray and cryo-EM structures of inhibitor-bound cytochrome bc(1) complexes for structure-based drug discovery #MMPMID29765610 Amporndanai K ; Johnson RM ; O'Neill PM ; Fishwick CWG ; Jamson AH ; Rawson S ; Muench SP ; Hasnain SS ; Antonyuk SV IUCrJ 2018[Mar]; 5 (Pt 2 ): 200-210 PMID29765610 show ga Cytochrome bc(1), a dimeric multi-subunit electron-transport protein embedded in the inner mitochondrial membrane, is a major drug target for the treatment and prevention of malaria and toxoplasmosis. Structural studies of cytochrome bc(1) from mammalian homologues co-crystallized with lead compounds have underpinned structure-based drug design to develop compounds with higher potency and selectivity. However, owing to the limited amount of cytochrome bc(1) that may be available from parasites, all efforts have been focused on homologous cytochrome bc(1) complexes from mammalian species, which has resulted in the failure of some drug candidates owing to toxicity in the host. Crystallographic studies of the native parasite proteins are not feasible owing to limited availability of the proteins. Here, it is demonstrated that cytochrome bc(1) is highly amenable to single-particle cryo-EM (which uses significantly less protein) by solving the apo and two inhibitor-bound structures to ?4.1?Å resolution, revealing clear inhibitor density at the binding site. Therefore, cryo-EM is proposed as a viable alternative method for structure-based drug discovery using both host and parasite enzymes. äX-ray and cryo-EM structures of inhibitor-bound cytochrome bc(1) compl(epmc).pdf DeepDyve Pubget Overpricing