Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/chem.201800992 http://scihub22266oqcxt.onion/10.1002/chem.201800992 C5947647!5947647!29504639     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Chemistry 2018 ; 24 (23): 6067-70 Nephropedia Template TP {{tp|p=29504639|t=2018. Efficient Detection of Structure and Dynamics in Unlabeled RNAs: The SELOPE Approach |pdf=|usr=}}{{29504639}} gab.com Text Efficient Detection of Structure and Dynamics in Unlabeled RNAs: The SELOPE Approach JO: Chemistry http://www.kidney.de/pget.php?&tw=1&pmid=29504639 #FOAvip The knowledge of structure and dynamics is crucial to explain the function of RNAs. While nuclear magnetic resonance (NMR) is well suited to probe these for complex biomolecules, it requires expensive, isotopically labeled samples, and long measurement times. Here we present SELOPE, a new robust, proton?only NMR method that allows us to obtain site?specific overview of structure and dynamics in an entire RNA molecule using an unlabeled sample. SELOPE simplifies assignment and allows for cost?effective screening of the response of nucleic acids to physiological changes (e.g. ion concentration) or screening of drugs in a high throughput fashion. This single technique allows us to probe an unprecedented range of exchange time scales (the whole ?s to ms motion range) with increased sensitivity, surpassing all current experiments to detect chemical exchange. For the first time we could describe an RNA excited state using an unlabeled RNA. Twit Text FOAVip Efficient Detection of Structure and Dynamics in Unlabeled RNAs: The SELOPE Approach ????Chemistry http://www.kidney.de/pget.php?&tw=1&pmid=29504639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29504639 #FOAvip English Wikipedia <ref>{{Cite pmid|29504639}}</ref> Efficient Detection of Structure and Dynamics in Unlabeled RNAs: The SELOPE Approach #MMPMID29504639 Schlagnitweit J; Steiner E; Karlsson H; Petzold K Chemistry 2018[Apr]; 24 (23): 6067-70 PMID29504639show ga The knowledge of structure and dynamics is crucial to explain the function of RNAs. While nuclear magnetic resonance (NMR) is well suited to probe these for complex biomolecules, it requires expensive, isotopically labeled samples, and long measurement times. Here we present SELOPE, a new robust, proton?only NMR method that allows us to obtain site?specific overview of structure and dynamics in an entire RNA molecule using an unlabeled sample. SELOPE simplifies assignment and allows for cost?effective screening of the response of nucleic acids to physiological changes (e.g. ion concentration) or screening of drugs in a high throughput fashion. This single technique allows us to probe an unprecedented range of exchange time scales (the whole ?s to ms motion range) with increased sensitivity, surpassing all current experiments to detect chemical exchange. For the first time we could describe an RNA excited state using an unlabeled RNA. äEfficient Detection of Structure and Dynamics in Unlabeled RNAs: The S(epmc).pdf DeepDyve Pubget Overpricing