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10.1111/1348-0421.12583 http://scihub22266oqcxt.onion/10.1111/1348-0421.12583 C5947646!5947646!29504148     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microbiol+Immunol 2018 ; 62 (4): 281-90 Nephropedia Template TP {{tp|p=29504148|t=2018. The immune characterization of interferon?? responses in tuberculosis patients |pdf=|usr=}}{{29504148}} gab.com Text The immune characterization of interferon responses in tuberculosis patients JO: Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29504148 #FOAvip We aimed to assess the immunoregulatory effects of IFN?? in patients with tuberculous pleurisy. IFN??, IFN?? and IL?17 expression levels were detected, and correlations among these factors in different culture groups were analyzed. Pleural fluid mononuclear cells (PFMC) from tuberculous pleural effusions, but not peripheral blood mononuclear cells (PBMC) from healthy donors, spontaneously expressed IFN??, IL?17 and IFN??. Moreover, exogenous IFN?? significantly inhibited the expression of IL?17 in PFMC. By contrast, IFN?? simultaneously enhanced the levels of IFN??. To further investigate the regulation of IL?17 and IFN?? by endogenous IFN??, an IFN?? neutralizing antibody was simultaneously added to bacillus Calmette?Guérin (BCG)?stimulated PFMC. IL?17 expression was significantly increased, but IFN?? production was markedly decreased in the experimental group supplemented with the IFN?? neutralizing antibody. Simultaneously, IL?17 production was remarkably increased in the experimental group supplemented with the IFN?? neutralizing antibody. Taken together, in our study, we first found that freshly isolated PFMC, but not PBMC from healthy donors, spontaneously expressed IFN??, IL?17 and IFN?? in vivo. Moreover, IFN?? suppressed IL?17 expression and increased IFN?? production. Furthermore, both IFN?? and IFN?? down?regulated IL?17 expression. These observations suggest that caution is required when basing anti?tuberculosis treatment on the inhibition of IFN?? signaling. Twit Text FOAVip The immune characterization of interferon responses in tuberculosis patients ????Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29504148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29504148 #FOAvip English Wikipedia <ref>{{Cite pmid|29504148}}</ref> The immune characterization of interferon?? responses in tuberculosis patients #MMPMID29504148 Zhang X; Sun Y; He C; Qiu X; Zhou D; Ye Z; Long Y; Tang T; Su X; Ma J Microbiol Immunol 2018[Apr]; 62 (4): 281-90 PMID29504148show ga We aimed to assess the immunoregulatory effects of IFN?? in patients with tuberculous pleurisy. IFN??, IFN?? and IL?17 expression levels were detected, and correlations among these factors in different culture groups were analyzed. Pleural fluid mononuclear cells (PFMC) from tuberculous pleural effusions, but not peripheral blood mononuclear cells (PBMC) from healthy donors, spontaneously expressed IFN??, IL?17 and IFN??. Moreover, exogenous IFN?? significantly inhibited the expression of IL?17 in PFMC. By contrast, IFN?? simultaneously enhanced the levels of IFN??. To further investigate the regulation of IL?17 and IFN?? by endogenous IFN??, an IFN?? neutralizing antibody was simultaneously added to bacillus Calmette?Guérin (BCG)?stimulated PFMC. IL?17 expression was significantly increased, but IFN?? production was markedly decreased in the experimental group supplemented with the IFN?? neutralizing antibody. Simultaneously, IL?17 production was remarkably increased in the experimental group supplemented with the IFN?? neutralizing antibody. Taken together, in our study, we first found that freshly isolated PFMC, but not PBMC from healthy donors, spontaneously expressed IFN??, IL?17 and IFN?? in vivo. Moreover, IFN?? suppressed IL?17 expression and increased IFN?? production. Furthermore, both IFN?? and IFN?? down?regulated IL?17 expression. These observations suggest that caution is required when basing anti?tuberculosis treatment on the inhibition of IFN?? signaling. äThe immune characterization of interferon?? responses in tuberculosis (epmc).pdf DeepDyve Pubget Overpricing