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Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 FEBS+J 2018 ; 285 (8): 1399-402 Nephropedia Template TP
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Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via activation of synergistic BMP and Notch signaling #MMPMID29654706
Osmanagic?Myers S; Rezniczek GA
FEBS J 2018[Apr]; 285 (8): 1399-402 PMID29654706show ga
Two extracellular BMP modulators, BMPER and TWSG1, act in a pro?BMP fashion to activate endothelial?specific members of the TGF??/BMP receptor family. Through cross?talk with the Notch signaling pathways, they are key regulators of downstream Notch targets, including ephrin B2. This adds to our understanding of BMP and Notch signaling, how these pathways converge, and thereby control arteriovenous specification.