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2018 ; 285
(8
): 1399-1402
Nephropedia Template TP
gab.com Text
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Arteriovenous specification: BMPER and TWSG1 determine endothelial cell fate via
activation of synergistic BMP and Notch signaling
#MMPMID29654706
Osmanagic-Myers S
; Rezniczek GA
FEBS J
2018[Apr]; 285
(8
): 1399-1402
PMID29654706
show ga
Two extracellular BMP modulators, BMPER and TWSG1, act in a pro-BMP fashion to
activate endothelial-specific members of the TGF-?/BMP receptor family. Through
cross-talk with the Notch signaling pathways, they are key regulators of
downstream Notch targets, including ephrin B2. This adds to our understanding of
BMP and Notch signaling, how these pathways converge, and thereby control
arteriovenous specification.