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10.1002/cpt.1010

http://scihub22266oqcxt.onion/10.1002/cpt.1010
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C5947521!5947521!29315510
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suck abstract from ncbi


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pmid29315510      Clin+Pharmacol+Ther 2018 ; 103 (5): 802-14
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  • Developing Drugs for Heart Failure With Reduced Ejection Fraction: What Have We Learned From Clinical Trials? #MMPMID29315510
  • Hinder M; Yi BA; Langenickel TH
  • Clin Pharmacol Ther 2018[May]; 103 (5): 802-14 PMID29315510show ga
  • There remains a large unmet need for new therapies in the treatment of heart failure with reduced ejection fraction (HFrEF). In the early drug development phase, the therapeutic potential of a drug is not yet fully understood and trial endpoints other than mortality are needed to guide drug development decisions. While a true surrogate marker for mortality in heart failure (HF) remains elusive, the successes and failures of previous trials can reveal markers that support clinical Go/NoGo decisions.
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