Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/1348-0421.12575 http://scihub22266oqcxt.onion/10.1111/1348-0421.12575 C5947265!5947265!29350405     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microbiol+Immunol 2018 ; 62 (4): 229-42 Nephropedia Template TP {{tp|p=29350405|t=2018. Reactive oxygen species?induced parthanatos of immunocytes by human cytomegalovirus?associated substance |pdf=|usr=}}{{29350405}} gab.com Text Reactive oxygen species induced parthanatos of immunocytes by human cytomegalovirus associated substance JO: Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29350405 #FOAvip Previous studies have examined various immune evasion strategies of human cytomegalovirus (HCMV) to gain understanding of its pathogenesis. Although the mechanism that underlies immunocyte destruction near HCMV?infected lesions has yet to be established, it is here shown that substances produced by HCMV?infected cells induce death in several types of immunocytes, but not in fibroblasts or astrocytomas. These substances contain HCMV proteins and were termed HCMV?associated insoluble substance (HCMVAIS). The mechanism by which HCMVAIS induces cell death was characterized to improve understanding the death of immunocytes near HCMV?infected lesions. HCMVAIS were found to trigger production of intracellular nicotinamide adenine dinucleotide phosphate oxidase?derived reactive oxygen species (ROS), resulting in cell death, this effect being reversed following treatment with ROS inhibitors. Cell death was not induced in splenocytes from NOX?2 knockout mice. It was hypothesized that DNA damage induced by oxidative stress initiates poly ADP?ribose polymerase?1 (PARP?1)?mediated cell death, or parthanatos. HCMVAIS?induced cell death is accompanied by PARP?1 activation in a caspase?independent manner, nuclear translocation of apoptosis?inducing factor (AIF), and DNA fragmentation, which are typical features of parthanatos. Treatment with an AIF inhibitor decreased the rate of HCMVAIS?induced cell death, this being confirmed by hematoxylin and eosin staining; cell death in most HCMV?positive foci in serial section samples of a large intestine with HCMV infection was TUNEL?positive, cleaved caspase 3?negative and CD45?positive. Taken together, these data suggest that HCMV inhibits local immune responses via direct killing of immunocytes near HCMV?infected cells through ROS?induced parthanatos by HCMVAIS. Twit Text FOAVip Reactive oxygen species induced parthanatos of immunocytes by human cytomegalovirus associated substance ????Microbiol Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29350405 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29350405 #FOAvip English Wikipedia <ref>{{Cite pmid|29350405}}</ref> Reactive oxygen species?induced parthanatos of immunocytes by human cytomegalovirus?associated substance #MMPMID29350405 Kim JH; Kim J; Roh J; Park C; Seoh J; Hwang E Microbiol Immunol 2018[Apr]; 62 (4): 229-42 PMID29350405show ga Previous studies have examined various immune evasion strategies of human cytomegalovirus (HCMV) to gain understanding of its pathogenesis. Although the mechanism that underlies immunocyte destruction near HCMV?infected lesions has yet to be established, it is here shown that substances produced by HCMV?infected cells induce death in several types of immunocytes, but not in fibroblasts or astrocytomas. These substances contain HCMV proteins and were termed HCMV?associated insoluble substance (HCMVAIS). The mechanism by which HCMVAIS induces cell death was characterized to improve understanding the death of immunocytes near HCMV?infected lesions. HCMVAIS were found to trigger production of intracellular nicotinamide adenine dinucleotide phosphate oxidase?derived reactive oxygen species (ROS), resulting in cell death, this effect being reversed following treatment with ROS inhibitors. Cell death was not induced in splenocytes from NOX?2 knockout mice. It was hypothesized that DNA damage induced by oxidative stress initiates poly ADP?ribose polymerase?1 (PARP?1)?mediated cell death, or parthanatos. HCMVAIS?induced cell death is accompanied by PARP?1 activation in a caspase?independent manner, nuclear translocation of apoptosis?inducing factor (AIF), and DNA fragmentation, which are typical features of parthanatos. Treatment with an AIF inhibitor decreased the rate of HCMVAIS?induced cell death, this being confirmed by hematoxylin and eosin staining; cell death in most HCMV?positive foci in serial section samples of a large intestine with HCMV infection was TUNEL?positive, cleaved caspase 3?negative and CD45?positive. Taken together, these data suggest that HCMV inhibits local immune responses via direct killing of immunocytes near HCMV?infected cells through ROS?induced parthanatos by HCMVAIS. äReactive oxygen species?induced parthanatos of immunocytes by human cy(epmc).pdf DeepDyve Pubget Overpricing