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10.1177/1559325818774421 http://scihub22266oqcxt.onion/10.1177/1559325818774421 C5946624!5946624!29770107     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Dose+Response 2018 ; 16 (2): ä Nephropedia Template TP {{tp|p=29770107|t=2018. Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses |pdf=|usr=}}{{29770107}} gab.com Text Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses JO: Dose Response http://www.kidney.de/pget.php?&tw=1&pmid=29770107 #FOAvip Recently, electron transfers and catalyses in a bevy of redox reactions mediated by hemeproteins were explained by murburn concept. The term ?murburn? is abstracted from ?muredburning? or ?mildunrestrictedburning? and connotes a novel ?molecule-unbound ion?radical? interaction paradigm. Quite unlike the genetic regulations and protein-level affinity-based controls that govern order and specificity/selectivity in conventional treatments, murburn concept is based on stochastic/thermodynamic regulatory principles. The novel insight necessitates a ?reactivity outside the active-site? perspective, because select redox enzymatic activity is obligatorily mediated via diffusible radical/species. Herein, reactions employing key hemeproteins (as exemplified by CYP2E1) establish direct experimental connection between ?additive-influenced redox catalysis? and ?unusual dose responses? in reductionist and physiological milieu. Thus, direct and conclusive molecular-level experimental evidence is presented, supporting the mechanistic relevance of murburn concept in ?maverick? concentration-based effects brought about by additives. Therefore, murburn concept could potentially explain several physiological hormetic and idiosyncratic dose responses. Twit Text FOAVip Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses ????Dose Response http://www.kidney.de/pget.php?&tw=1&pmid=29770107 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29770107 #FOAvip English Wikipedia <ref>{{Cite pmid|29770107}}</ref> Murburn Concept: A Molecular Explanation for Hormetic and Idiosyncratic Dose Responses #MMPMID29770107 Parashar A; Gideon DA; Manoj KM Dose Response 2018[Apr]; 16 (2): ä PMID29770107show ga Recently, electron transfers and catalyses in a bevy of redox reactions mediated by hemeproteins were explained by murburn concept. The term ?murburn? is abstracted from ?muredburning? or ?mildunrestrictedburning? and connotes a novel ?molecule-unbound ion?radical? interaction paradigm. Quite unlike the genetic regulations and protein-level affinity-based controls that govern order and specificity/selectivity in conventional treatments, murburn concept is based on stochastic/thermodynamic regulatory principles. The novel insight necessitates a ?reactivity outside the active-site? perspective, because select redox enzymatic activity is obligatorily mediated via diffusible radical/species. Herein, reactions employing key hemeproteins (as exemplified by CYP2E1) establish direct experimental connection between ?additive-influenced redox catalysis? and ?unusual dose responses? in reductionist and physiological milieu. Thus, direct and conclusive molecular-level experimental evidence is presented, supporting the mechanistic relevance of murburn concept in ?maverick? concentration-based effects brought about by additives. Therefore, murburn concept could potentially explain several physiological hormetic and idiosyncratic dose responses. äMurburn Concept: A Molecular Explanation for Hormetic and Idiosyncrati(epmc).pdf DeepDyve Pubget Overpricing