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10.3389/fimmu.2018.00902 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00902 C5946005!5946005 !29780383     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29780383 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Immunol 2018 ; 9 (ä): 902 Nephropedia Template TP {{tp|p=29780383 |t=2018. Human Metapneumovirus Infection Inhibits Cathelicidin Antimicrobial Peptide Expression in Human Macrophages |pdf=|usr=}}{{29780383 }} gab.com Text Human Metapneumovirus Infection Inhibits Cathelicidin Antimicrobial Peptide Expression in Human Macrophages JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29780383 #FOAvip Human cathelicidin antimicriobial peptide (CAMP) is a critical component of host innate immunity with both antimicrobial and immunomodulatory functions. Several pathogens have been shown to downregulate CAMP expression, yet it is unclear if such modulation occurs during a viral infection. In this study, we showed that infection with human metapneumovirus (hMPV), one of the leading causes of respiratory tract infections in young children, strongly suppressed basal and vitamin-D induced CAMP expression in human macrophages. hMPV-mediated suppression of CAMP did not correlate with reduced transcriptional expression of key vitamin D signaling components, such as CYP27B1 or vitamin D receptor, suggesting a vitamin D-independent mechanism. Blocking interferon-signaling pathways did not reverse hMVP-mediated suppression of CAMP, indicating that the suppressive effect is largely interferon-independent. Instead, we identified C/EBP? as the key modulator of hMPV-mediated suppression of CAMP. hMPV infection strongly repressed the expression of C/EBP?, and a knockdown study confirmed that C/EBP? is critical for CAMP expression in human macrophages. Such modulation of CAMP (and C/EBP?) could be reproduced by TLR1/2 ligand treatment in human macrophages, suggesting a common mechanism underlying pathogen-mediated downregulation of CAMP through C/EBP?. This study opens up a new understanding of altered human antimicrobial responses following infections. Twit Text FOAVip Human Metapneumovirus Infection Inhibits Cathelicidin Antimicrobial Peptide Expression in Human Macrophages ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29780383 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29780383 #FOAvip English Wikipedia <ref>{{Cite pmid|29780383 }}</ref> Human Metapneumovirus Infection Inhibits Cathelicidin Antimicrobial Peptide Expression in Human Macrophages #MMPMID29780383 Li Y ; Østerhus S ; Johnsen IB Front Immunol 2018[]; 9 (ä): 902 PMID29780383 show ga Human cathelicidin antimicriobial peptide (CAMP) is a critical component of host innate immunity with both antimicrobial and immunomodulatory functions. Several pathogens have been shown to downregulate CAMP expression, yet it is unclear if such modulation occurs during a viral infection. In this study, we showed that infection with human metapneumovirus (hMPV), one of the leading causes of respiratory tract infections in young children, strongly suppressed basal and vitamin-D induced CAMP expression in human macrophages. hMPV-mediated suppression of CAMP did not correlate with reduced transcriptional expression of key vitamin D signaling components, such as CYP27B1 or vitamin D receptor, suggesting a vitamin D-independent mechanism. Blocking interferon-signaling pathways did not reverse hMVP-mediated suppression of CAMP, indicating that the suppressive effect is largely interferon-independent. Instead, we identified C/EBP? as the key modulator of hMPV-mediated suppression of CAMP. hMPV infection strongly repressed the expression of C/EBP?, and a knockdown study confirmed that C/EBP? is critical for CAMP expression in human macrophages. Such modulation of CAMP (and C/EBP?) could be reproduced by TLR1/2 ligand treatment in human macrophages, suggesting a common mechanism underlying pathogen-mediated downregulation of CAMP through C/EBP?. This study opens up a new understanding of altered human antimicrobial responses following infections. |Animals [MESH] |Antimicrobial Cationic Peptides/genetics/immunology/*metabolism [MESH] |CCAAT-Enhancer-Binding Proteins/genetics/*metabolism [MESH] |Cathelicidins [MESH] |Cell Line [MESH] |Cells, Cultured [MESH] |Epithelial Cells [MESH] |Gene Expression Regulation/immunology [MESH] |Gene Knockdown Techniques [MESH] |Host-Pathogen Interactions/immunology [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Macaca mulatta [MESH] |Macrophages/*immunology/virology [MESH] |Metapneumovirus/*immunology [MESH] |Paramyxoviridae Infections/*immunology/virology [MESH] |RNA, Small Interfering/metabolism [MESH] |Virus Replication/immunology [MESH]Human Metapneumovirus Infection Inhibits Cathelicidin Antimicrobial Pe(epmc).pdf DeepDyve Pubget Overpricing