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10.3389/fimmu.2018.00977 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00977 C5945824!5945824 !29780393     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29780393 &cmd=llinks): Failed to open stream: HTTP request failed! 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Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities |pdf=|usr=}}{{29780393 }} gab.com Text Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29780393 #FOAvip Immunomodulatory drugs (IMiDs) are anticancer drugs with immunomodulatory, anti-angiogenesis, anti-proliferative, and pro-apoptotic properties. IMiDs are currently used for the treatment of multiple myeloma, myelodysplastic syndrome, and B-cell lymphoma; however, little is known about efficacy in acute myeloid leukemia (AML). We proposed in this study to investigate the relevance of IMiDs therapy for AML treatment. We evaluated the effect of IMiDs on primary AML blasts (n?=?24), and the impact in natural killer (NK) cell-mediated immunosurveillance of AML. Using primary AML cells and an immunodeficient mouse leukemia xenograft model, we showed that IMiDs induce AML cell death in vitro and impair leukemia progression in vivo. In addition, treatment of AML blasts with IMiDs resulted in enhanced allogeneic NK cell anti-leukemia reactivity. Treatment by pomalidomide of AML blasts enhanced lysis, degranulation, and cytokine production by primary allogeneic NK cells. Furthermore, the treatment with lenalidomide of patients with myeloid malignancies resulted in NK cell phenotypic changes similar to those observed in vitro. IMiDs increased CD56 and decreased NKp30, NKp46, and KIR2D expression on NK cells. Finally, AML blasts treatment with IMiDs induced phenotypic alterations including downregulation of HLA-class I. The effect of pomalidomide was not correlated with cereblon expression and A/G polymorphism in AML cells. Our data revealed, a yet unobserved, dual effects on AML affecting both AML survival and their sensitivity to NK immunotherapy using IMiDs. Our study encourages continuing investigation for the use of IMiDs in AML, especially in combination with conventional therapy or immunotherapy strategies. Twit Text FOAVip Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29780393 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29780393 #FOAvip English Wikipedia <ref>{{Cite pmid|29780393 }}</ref> Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Leukemia by Direct and Immunostimulatory Activities #MMPMID29780393 Le Roy A ; Prébet T ; Castellano R ; Goubard A ; Riccardi F ; Fauriat C ; Granjeaud S ; Benyamine A ; Castanier C ; Orlanducci F ; Ben Amara A ; Pont F ; Fournié JJ ; Collette Y ; Mege JL ; Vey N ; Olive D Front Immunol 2018[]; 9 (ä): 977 PMID29780393 show ga Immunomodulatory drugs (IMiDs) are anticancer drugs with immunomodulatory, anti-angiogenesis, anti-proliferative, and pro-apoptotic properties. IMiDs are currently used for the treatment of multiple myeloma, myelodysplastic syndrome, and B-cell lymphoma; however, little is known about efficacy in acute myeloid leukemia (AML). We proposed in this study to investigate the relevance of IMiDs therapy for AML treatment. We evaluated the effect of IMiDs on primary AML blasts (n?=?24), and the impact in natural killer (NK) cell-mediated immunosurveillance of AML. Using primary AML cells and an immunodeficient mouse leukemia xenograft model, we showed that IMiDs induce AML cell death in vitro and impair leukemia progression in vivo. In addition, treatment of AML blasts with IMiDs resulted in enhanced allogeneic NK cell anti-leukemia reactivity. Treatment by pomalidomide of AML blasts enhanced lysis, degranulation, and cytokine production by primary allogeneic NK cells. Furthermore, the treatment with lenalidomide of patients with myeloid malignancies resulted in NK cell phenotypic changes similar to those observed in vitro. IMiDs increased CD56 and decreased NKp30, NKp46, and KIR2D expression on NK cells. Finally, AML blasts treatment with IMiDs induced phenotypic alterations including downregulation of HLA-class I. The effect of pomalidomide was not correlated with cereblon expression and A/G polymorphism in AML cells. Our data revealed, a yet unobserved, dual effects on AML affecting both AML survival and their sensitivity to NK immunotherapy using IMiDs. Our study encourages continuing investigation for the use of IMiDs in AML, especially in combination with conventional therapy or immunotherapy strategies. |Aged [MESH] |Aged, 80 and over [MESH] |Animals [MESH] |Antineoplastic Agents/*therapeutic use [MESH] |CD56 Antigen/genetics/immunology [MESH] |Cells, Cultured [MESH] |Cytotoxicity, Immunologic [MESH] |Genes, MHC Class I [MESH] |Humans [MESH] |Immunologic Factors/*therapeutic use [MESH] |K562 Cells [MESH] |Killer Cells, Natural/*immunology [MESH] |Lenalidomide/therapeutic use [MESH] |Leukemia, Myeloid, Acute/*drug therapy/*immunology [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Monitoring, Immunologic [MESH] |Natural Cytotoxicity Triggering Receptor 3/genetics/immunology [MESH] |Thalidomide/analogs & derivatives/therapeutic use [MESH]Immunomodulatory Drugs Exert Anti-Leukemia Effects in Acute Myeloid Le(epmc).pdf DeepDyve Pubget Overpricing