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10.1038/s41419-018-0568-z http://scihub22266oqcxt.onion/10.1038/s41419-018-0568-z C5945780!5945780!29749404     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2018 ; 9 (5): ä Nephropedia Template TP {{tp|p=29749404|t=2018. Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis |pdf=|usr=}}{{29749404}} gab.com Text Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29749404 #FOAvip Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement of the DN in Hb kidney injury was suggested by the induction of renal hepcidin synthesis (p?<?0.001) in mice repeatedly injected with intravenous Hb. Moreover, the hepcidin induction was associated with a decline in urinary kidney injury markers 24p3/NGAL and KIM1, suggesting a role for hepcidin in protection against Hb kidney injury. We demonstrated that uptake of Hb in the mouse cortical collecting duct cells (mCCDcl1) is mediated by multi-protein ligand receptor 24p3R, as indicated by a significant 90% reduction in Hb uptake (p?<?0.001) after 24p3R silencing. Moreover, incubation of mCCDcl1 cells with Hb or hemin for 4 or 24?h resulted in hepcidin synthesis and increased mRNA expression of markers for oxidative, inflammatory and ER stress, but no cell death as indicated by apoptosis staining. A protective role for cellular hepcidin against Hb-induced injury was demonstrated by aggravation of oxidative, inflammatory and ER stress after 4?h Hb or hemin incubation in hepcidin silenced mCCDcl1 cells. Hepcidin silencing potentiated hemin-mediated cell death that could be diminished by co-incubation of Nec-1, suggesting that endogenous hepcidin prevents necroptosis. Combined, these results demonstrate that renal hepcidin synthesis protects the DN against hemin and hemoglobin-mediated injury. Twit Text FOAVip Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=29749404 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29749404 #FOAvip English Wikipedia <ref>{{Cite pmid|29749404}}</ref> Endogenous hepcidin synthesis protects the distal nephron against hemin and hemoglobin mediated necroptosis #MMPMID29749404 van Swelm RPL; Vos M; Verhoeven F; Thévenod F; Swinkels DW Cell Death Dis 2018[May]; 9 (5): ä PMID29749404show ga Hemoglobinuria is associated with kidney injury in various hemolytic pathologies. Currently, there is no treatment available and its pathophysiology is not completely understood. Here we studied the potential detrimental effects of hemoglobin (Hb) exposure to the distal nephron (DN). Involvement of the DN in Hb kidney injury was suggested by the induction of renal hepcidin synthesis (p? äEndogenous hepcidin synthesis protects the distal nephron against hemi(epmc).pdf DeepDyve Pubget Overpricing