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10.1038/s41467-018-03962-x http://scihub22266oqcxt.onion/10.1038/s41467-018-03962-x C5945639!5945639 !29748571     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29748571 &cmd=llinks): Failed to open stream: HTTP request failed! 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TGF-? induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression |pdf=|usr=}}{{29748571 }} gab.com Text TGF- induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29748571 #FOAvip TGF-?/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this response have remained yet undetermined. Here, we show that TGF-? transcriptionally induces MIR100HG lncRNA, containing miR-100, miR-125b and let-7a in its intron, via SMAD2/3. Interestingly, we find that although the pro-tumourigenic miR-100 and miR-125b accordingly increase, the amount of anti-tumourigenic let-7a is unchanged, as TGF-? also induces LIN28B inhibiting its maturation. Notably, we demonstrate that inactivation of miR-125b or miR-100 affects the TGF-?-mediated response indicating that these miRNAs are important TGF-? effectors. We integrate AGO2-RIP-seq with RNA-seq to identify the global regulation exerted by these miRNAs in PDAC cells. Transcripts targeted by miR-125b and miR-100 significantly overlap and mainly inhibit p53 and cell-cell junctions' pathways. Together, we uncover that TGF-? induces an lncRNA, whose encoded miRNAs, miR-100, let-7a and miR-125b play opposing roles in controlling PDAC tumourigenesis. Twit Text FOAVip TGF- induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29748571 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29748571 #FOAvip English Wikipedia <ref>{{Cite pmid|29748571 }}</ref> TGF-? induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression #MMPMID29748571 Ottaviani S ; Stebbing J ; Frampton AE ; Zagorac S ; Krell J ; de Giorgio A ; Trabulo SM ; Nguyen VTM ; Magnani L ; Feng H ; Giovannetti E ; Funel N ; Gress TM ; Jiao LR ; Lombardo Y ; Lemoine NR ; Heeschen C ; Castellano L Nat Commun 2018[May]; 9 (1 ): 1845 PMID29748571 show ga TGF-?/Activin induces epithelial-to-mesenchymal transition and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this response have remained yet undetermined. Here, we show that TGF-? transcriptionally induces MIR100HG lncRNA, containing miR-100, miR-125b and let-7a in its intron, via SMAD2/3. Interestingly, we find that although the pro-tumourigenic miR-100 and miR-125b accordingly increase, the amount of anti-tumourigenic let-7a is unchanged, as TGF-? also induces LIN28B inhibiting its maturation. Notably, we demonstrate that inactivation of miR-125b or miR-100 affects the TGF-?-mediated response indicating that these miRNAs are important TGF-? effectors. We integrate AGO2-RIP-seq with RNA-seq to identify the global regulation exerted by these miRNAs in PDAC cells. Transcripts targeted by miR-125b and miR-100 significantly overlap and mainly inhibit p53 and cell-cell junctions' pathways. Together, we uncover that TGF-? induces an lncRNA, whose encoded miRNAs, miR-100, let-7a and miR-125b play opposing roles in controlling PDAC tumourigenesis. |Animals [MESH] |Carcinogenesis/genetics [MESH] |Carcinoma, Pancreatic Ductal/*genetics/pathology [MESH] |Cell Line, Tumor [MESH] |Datasets as Topic [MESH] |Disease Progression [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Humans [MESH] |Introns/genetics [MESH] |Mice [MESH] |Mice, Nude [MESH] |MicroRNAs/antagonists & inhibitors/*genetics/metabolism [MESH] |Pancreas/pathology [MESH] |Pancreatic Neoplasms/*genetics/pathology [MESH] |RNA, Small Interfering/metabolism [MESH] |RNA-Binding Proteins/*genetics/metabolism [MESH] |Signal Transduction/genetics [MESH] |Transforming Growth Factor beta1/*metabolism [MESH] |Up-Regulation [MESH]TGF-? induces miR-100 and miR-125b but blocks let-7a through LIN28B co(epmc).pdf DeepDyve Pubget Overpricing