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10.1038/s41467-018-04222-8 http://scihub22266oqcxt.onion/10.1038/s41467-018-04222-8 C5945617!5945617 !29748611     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29748611 &cmd=llinks): Failed to open stream: HTTP request failed! 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Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes |pdf=|usr=}}{{29748611 }} gab.com Text Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29748611 #FOAvip Fluorescence and photoacoustic imaging have different advantages in cancer diagnosis; however, combining effects in one agent normally requires a trade-off as the mechanisms interfere. Here, based on rational molecular design, we introduce a smart organic nanoparticle whose absorbed excitation energy can be photo-switched to the pathway of thermal deactivation for photoacoustic imaging, or to allow opposed routes for fluorescence imaging and photodynamic therapy. The molecule is made of a dithienylethene (DTE) core with two surrounding 2-(1-(4-(1,2,2-triphenylvinyl)phenyl)ethylidene)malononitrile (TPECM) units (DTE-TPECM). The photosensitive molecule changes from a ring-closed, for photoacoustic imaging, to a ring-opened state for fluorescence and photodynamic effects upon an external light trigger. The nanoparticles' photoacoustic and fluorescence imaging properties demonstrate the advantage of the switch. The use of the nanoparticles improves the outcomes of in vivo cancer surgery using preoperative photoacoustic imaging and intraoperative fluorescent visualization/photodynamic therapy of residual tumours to ensure total tumour removal. Twit Text FOAVip Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29748611 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29748611 #FOAvip English Wikipedia <ref>{{Cite pmid|29748611 }}</ref> Light-driven transformable optical agent with adaptive functions for boosting cancer surgery outcomes #MMPMID29748611 Qi J ; Chen C ; Zhang X ; Hu X ; Ji S ; Kwok RTK ; Lam JWY ; Ding D ; Tang BZ Nat Commun 2018[May]; 9 (1 ): 1848 PMID29748611 show ga Fluorescence and photoacoustic imaging have different advantages in cancer diagnosis; however, combining effects in one agent normally requires a trade-off as the mechanisms interfere. Here, based on rational molecular design, we introduce a smart organic nanoparticle whose absorbed excitation energy can be photo-switched to the pathway of thermal deactivation for photoacoustic imaging, or to allow opposed routes for fluorescence imaging and photodynamic therapy. The molecule is made of a dithienylethene (DTE) core with two surrounding 2-(1-(4-(1,2,2-triphenylvinyl)phenyl)ethylidene)malononitrile (TPECM) units (DTE-TPECM). The photosensitive molecule changes from a ring-closed, for photoacoustic imaging, to a ring-opened state for fluorescence and photodynamic effects upon an external light trigger. The nanoparticles' photoacoustic and fluorescence imaging properties demonstrate the advantage of the switch. The use of the nanoparticles improves the outcomes of in vivo cancer surgery using preoperative photoacoustic imaging and intraoperative fluorescent visualization/photodynamic therapy of residual tumours to ensure total tumour removal. |Animals [MESH] |Antineoplastic Agents/*chemistry/therapeutic use [MESH] |Cell Line, Tumor [MESH] |Chemotherapy, Adjuvant/methods [MESH] |Female [MESH] |Humans [MESH] |Intraoperative Period [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Nanoparticles/*chemistry/therapeutic use [MESH] |Neoplasms/diagnostic imaging/mortality/*therapy [MESH] |Optical Imaging/*methods [MESH] |Photoacoustic Techniques/methods [MESH] |Photochemotherapy/*methods [MESH] |Photosensitizing Agents/*chemistry/therapeutic use [MESH] |Preoperative Period [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Survival Rate [MESH] |Temperature [MESH] |Treatment Outcome [MESH]Light-driven transformable optical agent with adaptive functions for b(epmc).pdf DeepDyve Pubget Overpricing