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10.1038/s41388-018-0136-0 http://scihub22266oqcxt.onion/10.1038/s41388-018-0136-0 C5945579!5945579 !29449696     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29449696 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncogene 2018 ; 37 (19 ): 2515-2531 Nephropedia Template TP {{tp|p=29449696 |t=2018. Snail regulates BMP and TGF? pathways to control the differentiation status of glioma-initiating cells |pdf=|usr=}}{{29449696 }} gab.com Text Snail regulates BMP and TGF pathways to control the differentiation status of glioma-initiating cells JO: Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=29449696 #FOAvip Glioblastoma multiforme is a brain malignancy characterized by high heterogeneity, invasiveness, and resistance to current therapies, attributes related to the occurrence of glioma stem cells (GSCs). Transforming growth factor ? (TGF?) promotes self-renewal and bone morphogenetic protein (BMP) induces differentiation of GSCs. BMP7 induces the transcription factor Snail to promote astrocytic differentiation in GSCs and suppress tumor growth in vivo. We demonstrate that Snail represses stemness in GSCs. Snail interacts with SMAD signaling mediators, generates a positive feedback loop of BMP signaling and transcriptionally represses the TGFB1 gene, decreasing TGF?1 signaling activity. Exogenous TGF?1 counteracts Snail function in vitro, and in vivo promotes proliferation and re-expression of Nestin, confirming the importance of TGFB1 gene repression by Snail. In conclusion, novel insight highlights mechanisms whereby Snail differentially regulates the activity of the opposing BMP and TGF? pathways, thus promoting an astrocytic fate switch and repressing stemness in GSCs. Twit Text FOAVip Snail regulates BMP and TGF pathways to control the differentiation status of glioma-initiating cells ????Oncogene http://www.kidney.de/pget.php?&tw=1&pmid=29449696 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29449696 #FOAvip English Wikipedia <ref>{{Cite pmid|29449696 }}</ref> Snail regulates BMP and TGF? pathways to control the differentiation status of glioma-initiating cells #MMPMID29449696 Caja L ; Tzavlaki K ; Dadras MS ; Tan EJ ; Hatem G ; Maturi NP ; Morén A ; Wik L ; Watanabe Y ; Savary K ; Kamali-Moghaddan M ; Uhrbom L ; Heldin CH ; Moustakas A Oncogene 2018[May]; 37 (19 ): 2515-2531 PMID29449696 show ga Glioblastoma multiforme is a brain malignancy characterized by high heterogeneity, invasiveness, and resistance to current therapies, attributes related to the occurrence of glioma stem cells (GSCs). Transforming growth factor ? (TGF?) promotes self-renewal and bone morphogenetic protein (BMP) induces differentiation of GSCs. BMP7 induces the transcription factor Snail to promote astrocytic differentiation in GSCs and suppress tumor growth in vivo. We demonstrate that Snail represses stemness in GSCs. Snail interacts with SMAD signaling mediators, generates a positive feedback loop of BMP signaling and transcriptionally represses the TGFB1 gene, decreasing TGF?1 signaling activity. Exogenous TGF?1 counteracts Snail function in vitro, and in vivo promotes proliferation and re-expression of Nestin, confirming the importance of TGFB1 gene repression by Snail. In conclusion, novel insight highlights mechanisms whereby Snail differentially regulates the activity of the opposing BMP and TGF? pathways, thus promoting an astrocytic fate switch and repressing stemness in GSCs. |*Signal Transduction [MESH] |Animals [MESH] |Bone Morphogenetic Proteins/metabolism [MESH] |Brain Neoplasms/genetics/*metabolism [MESH] |Cell Differentiation [MESH] |Cell Line, Tumor [MESH] |Gene Expression Profiling/*methods [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Glioblastoma/genetics/*metabolism [MESH] |Humans [MESH] |Mice [MESH] |Neoplasm Transplantation [MESH] |Neoplastic Stem Cells/*cytology/metabolism/pathology [MESH] |Snail Family Transcription Factors/metabolism [MESH]Snail regulates BMP and TGF? pathways to control the differentiation s(epmc).pdf DeepDyve Pubget Overpricing