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2018 ; 9
(29
): 20891-20907
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Natural killer cells as a therapeutic tool for infectious diseases - current
status and future perspectives
#MMPMID29755697
Schmidt S
; Tramsen L
; Rais B
; Ullrich E
; Lehrnbecher T
Oncotarget
2018[Apr]; 9
(29
): 20891-20907
PMID29755697
show ga
Natural Killer (NK) cells are involved in the host immune response against
infections due to viral, bacterial and fungal pathogens, all of which are a
significant cause of morbidity and mortality in immunocompromised patients. Since
the recovery of the immune system has a major impact on the outcome of an
infectious complication, there is major interest in strengthening the host
response in immunocompromised patients, either by using cytokines or growth
factors or by adoptive cellular therapies transfusing immune cells such as
granulocytes or pathogen-specific T-cells. To date, relatively little is known
about the potential of adoptively transferring NK cells in immunocompromised
patients with infectious complications, although the anti-cancer property of NK
cells is already being investigated in the clinical setting. This review will
focus on the antimicrobial properties of NK cells and the current standing and
future perspectives of generating and using NK cells as immunotherapy in patients
with infectious complications, an approach which is promising and might have an
important clinical impact in the future.