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10.1371/journal.pone.0197258

http://scihub22266oqcxt.onion/10.1371/journal.pone.0197258
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C5945012!5945012!29746605
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suck abstract from ncbi

pmid29746605      PLoS+One 2018 ; 13 (5): ä
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  • Daily variation of gene expression in diverse rat tissues #MMPMID29746605
  • Mavroudis PD; DuBois DC; Almon RR; Jusko WJ
  • PLoS One 2018[]; 13 (5): ä PMID29746605show ga
  • Circadian information is maintained in mammalian tissues by a cell-autonomous network of transcriptional feedback loops that have evolved to optimally regulate tissue-specific functions. An analysis of daily gene expression in different tissues, as well as an evaluation of inter-tissue circadian variability, is crucial for a systems-level understanding of this transcriptional circuitry. Affymetrix gene chip measurements of liver, muscle, adipose, and lung tissues were obtained from a rich time series light/dark experiment, involving 54 normal rats sacrificed at 18 time points within the 24-hr cycle. Our analysis revealed a high degree of circadian regulation with a variable distribution of phases among the four tissues. Interestingly, only a small number of common genes maintain circadian activity in all tissues, with many of them consisting of ?core-clock? components with synchronous rhythms. Our results suggest that inter-tissue circadian variability is a critical component of homeostatic body function and is mediated by diverse signaling pathways that ultimately lead to highly tissue-specific transcription regulation.
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