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2018 ; 8
(1
): 1-11
Nephropedia Template TP
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English Wikipedia
Molecular Epidemiology of Multidrug-Resistant Bacteria Isolated from Libyan and
Syrian Patients with War Injuries in Two Bundeswehr Hospitals in Germany
#MMPMID29760959
Frickmann H
; Köller T
; Hagen RM
; Ebert KP
; Müller M
; Wenzel W
; Gatzer R
; Schotte U
; Binder A
; Skusa R
; Warnke P
; Podbielski A
; Rückert C
; Kreikemeyer B
Eur J Microbiol Immunol (Bp)
2018[Apr]; 8
(1
): 1-11
PMID29760959
show ga
INTRODUCTION: We assessed the molecular epidemiology of multidrug-resistant
bacteria colonizing or infecting war-injured patients from Libya and Syria who
were treated at the Bundeswehr hospitals Hamburg and Westerstede, Germany.
METHODS: Enterobacteriaceae and Gram-negative rod-shaped nonfermentative bacteria
with resistance against third-generation methoxyimino cephalosporins or
carbapenems as well as methicillin-resistant Staphylococcus aureus (MRSA) from
war-injured patients from Libya and Syria were assessed by molecular typing,
i.e., spa typing for MRSA strains and rep-PCR and next-generation sequencing
(NGS) for Gram-negative isolates. RESULTS: A total of 66 isolates were assessed -
comprising 44 Enterobacteriaceae, 16 nonfermentative rod-shaped bacteria, and 6
MRSA from 22 patients - and 8 strains from an assessment of the patient
environment comprising 5 Enterobacteriaceae and 3 nonfermentative rod-shaped
bacteria. Although 24 out of 66 patient strains were isolated more than 3 days
after hospital admission, molecular typing suggested only 7 likely transmission
events in the hospitals. Identified clonal clusters primarily suggested
transmission events in the country of origin or during the medical evacuation
flights. CONCLUSIONS: Nosocomial transmissions in hospital can be efficiently
prevented by hygiene precautions in spite of heavy colonization. Transmission
prior to hospital admission like on evacuation flights or in crises zones needs
further assessment.